EIPM Seminar Series: "The Highs and Lows (-plex) of Spatial Biology in Autoimmune Research" M. Caleb Marlin, PhD

Englander Institute for Precision Medicine Seminar Series "The Highs and Lows (-plex) of Spatial Biology in Autoimmune Research" Presented by M. Caleb Marlin, PhD Senior Scientist and Imaging Project Manager, Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation Description: Spatial biology is a growing field of impactful technologies and analysis tools that allow researchers to understand the cellular and molecular makeup of a given tissue in its native spatial context. This understanding provides a unique opportunity to answer questions that no other field of study can investigate. There exists a wide range of imaging technologies that identify different numbers of markers and/or different analytes altogether. Leveraging these seemingly disparate technologies together provide us with a more holistic understanding of the tissue in clinically meaningful ways. Here, Dr. Marlin will discuss how the Guthridge/James lab at the Oklahoma Medical Research Foundation is working with both high- and low-plex datasets to better understand afflicted tissues in autoimmunity. Bio: Dr. Caleb Marlin is a Senior Staff Scientist and Imaging Project Manager in the labs of Drs. Judith James and Joel Guthridge in the Arthritis and Clinical Immunology Research Program at the Oklahoma Medical Research Foundation. Their research focuses predominantly on understanding the underlying mechanisms contributing to autoimmune diseases like Lupus, Sjogren’s Disease, Rheumatoid Arthritis, and Multiple Sclerosis. With deep-phenotyping capabilities and single-cell technologies, in combination with their biorepository and local clinics, their group combines large informatics approaches with clinical data to better understand these diseases and better treat patients afflicted with autoimmunity.