Englander Institute for Precision Medicine

International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.

TitleInternational consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.
Publication TypeJournal Article
Year of Publication2024
AuthorsChen X, Tsvetkov AS, Shen H-M, Isidoro C, Ktistakis NT, Linkermann A, Koopman WJH, Simon H-U, Galluzzi L, Luo S, Xu D, Gu W, Peulen O, Cai Q, Rubinsztein DC, Chi J-T, Zhang DD, Li C, Toyokuni S, Liu J, Roh J-L, Dai E, Juhász G, Liu W, Zhang J, Yang M, Liu J, Zhu L-Q, Zou W, Piacentini M, Ding W-X, Yue Z, Xie Y, Petersen M, Gewirtz DA, Mandell MA, Chu CT, Sinha D, Eftekharpour E, Zhivotovsky B, Besteiro S, Gabrilovich DI, Kim D-H, Kagan VE, Bayir H, Chen G-C, Ayton S, Lünemann JD, Komatsu M, Krautwald S, Loos B, Baehrecke EH, Wang J, Lane JD, Sadoshima J, Yang WSeok, Gao M, Münz C, Thumm M, Kampmann M, Yu D, Lipinski MM, Jones JW, Jiang X, Zeh HJ, Kang R, Klionsky DJ, Kroemer G, Tang D
Date Published2024 Mar 05

Macroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through the selective degradation of anti-injury proteins or organelles. Conversely, other forms of selective autophagy (e.g. reticulophagy and lysophagy) enhance the cellular defense against ferroptotic damage. Dysregulated autophagy-dependent ferroptosis has implications for a diverse range of pathological conditions. This review aims to present an updated definition of autophagy-dependent ferroptosis, discuss influential substrates and receptors, outline experimental methods, and propose guidelines for interpreting the results.

Alternate JournalAutophagy
PubMed ID38442890
Grant ListBBS/E/B/000C0417 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom
R01 NS089737 / NS / NINDS NIH HHS / United States

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