Englander Institute for Precision Medicine

Type I interferon and cancer.

TitleType I interferon and cancer.
Publication TypeJournal Article
Year of Publication2024
AuthorsHolicek P, Guilbaud E, Klapp V, Truxova I, Spisek R, Galluzzi L, Fucikova J
JournalImmunol Rev
Date Published2024 Jan
KeywordsAntineoplastic Agents, Cytokines, Humans, Interferon Type I, Neoplasms, Tumor Microenvironment

Type I interferon (IFN) is a class of proinflammatory cytokines with a dual role on malignant transformation, tumor progression, and response to therapy. On the one hand, robust, acute, and resolving type I IFN responses have been shown to mediate prominent anticancer effects, reflecting not only their direct cytostatic/cytotoxic activity on (at least some) malignant cells, but also their pronounced immunostimulatory functions. In line with this notion, type I IFN signaling has been implicated in the antineoplastic effects of various immunogenic therapeutics, including (but not limited to) immunogenic cell death (ICD)-inducing agents and immune checkpoint inhibitors (ICIs). On the other hand, weak, indolent, and non-resolving type I IFN responses have been demonstrated to support tumor progression and resistance to therapy, reflecting the ability of suboptimal type I IFN signaling to mediate cytoprotective activity, promote stemness, favor tolerance to chromosomal instability, and facilitate the establishment of an immunologically exhausted tumor microenvironment. Here, we review fundamental aspects of type I IFN signaling and their context-dependent impact on malignant transformation, tumor progression, and response to therapy.

Alternate JournalImmunol Rev
PubMed ID37667466
Grant List / / Leukemia and Lymphoma Society /
CA271915 / / NIH/NCI /
/ / Sandra and Edward Meyer Cancer Center /
/ / Sotio Biotech /
#I16-0064 / / STARR Cancer Consortium /
/ / US DoD BCRP /
startup funds from the Dept. of Radiation Oncology / / Weill Cornell Medicine - Qatar /

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