Englander Institute for Precision Medicine

A guideline on the molecular ecosystem regulating ferroptosis.

TitleA guideline on the molecular ecosystem regulating ferroptosis.
Publication TypeJournal Article
Year of Publication2024
AuthorsDai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WSeok, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi J-T, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D
JournalNat Cell Biol
Date Published2024 Feb 29

Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.

Alternate JournalNat Cell Biol
PubMed ID38424270
PubMed Central ID3367386
Grant List733 310030_170320 / / U.S. Department of Health & Human Services | National Institutes of Health (NIH) /

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