| Title | A guideline on the molecular ecosystem regulating ferroptosis. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WSeok, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi J-T, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D |
| Journal | Nat Cell Biol |
| Date Published | 2024 Feb 29 |
| ISSN | 1476-4679 |
| Abstract | Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases. |
| DOI | 10.1038/s41556-024-01360-8 |
| Alternate Journal | Nat Cell Biol |
| PubMed ID | 38424270 |
| PubMed Central ID | 3367386 |
| Grant List | 733 310030_170320 / / U.S. Department of Health & Human Services | National Institutes of Health (NIH) / |