An enzyme called EZH2 has an unexpected role in driving aggressive tumor growth in treatment-resistant prostate cancers, according to a new study by scientists at Weill Cornell Medicine. The results could potentially lead to new therapies for patients with limited options and add to the significant progress the teams have made in understanding how advanced prostate cancer develops resistance to treatments that target androgen receptors.
![EIPM](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/screenshot_2024-12-23_at_8.12.38_am.png?itok=XMrz-Ooa)
January 2025 EIPM Director's Memo
January 1, 2025
Dear Members of the Englander Institute,
I hope everyone enjoyed the holiday season had a chance to reconnect with family and friends, and refresh yourselves for the year ahead.
![News from the EIPM!](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/screenshot_2024-02-26_at_10.01.35_am.png?itok=IMN5eTOt)
EIPM's Fourth Quarter 2024 External Newsletter!
December 31, 2024
EIPM's Fourth Quarter 2024 External Newsletter
December 31, 2024
![A clump of prostate cancer cells. The blue-green cells are growing, whereas the pink ones are dying by programmed cell death (apoptosis). Credit: Dave McCarthy and Annie Cavanagh/Wellcome Trust A clump of prostate cancer cells. The blue-green cells are growing, whereas the pink ones are dying by programmed cell death (apoptosis). Credit: Dave McCarthy and Annie Cavanagh/Wellcome Trust](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/screenshot_2024-12-16_at_11.22.40_am.png?itok=GZuiv5jJ)
Putting the Brakes on Prostate Cancer Cells
December 16, 2024
Prostate cancer hijacks the normal prostate’s growth regulation program to release the brakes and grow freely, according to Weill Cornell Medicine researchers. The discovery, published Dec. 13 in Nature Communications, paves the way for new diagnostic tests to guide treatment and could also help drug developers identify novel ways to stop the disease.
![Microscopic image of metastatic clear cell carcinoma of kidney, the most common type of renal cell carcinoma. Credit: Shutterstock](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/screenshot_2024-12-16_at_11.36.04_am.png?itok=vfbW1mDZ)
Finding Innovative Ways to Address Kidney Cancer Leads to DoD Grant
December 10, 2024
Weill Cornell Medicine has received a $1.4 million, four-year grant from the U.S. Department of Defense to investigate a new therapeutic approach for the most common form of kidney cancer.
![EIPM Director Olivier Elemento](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/dr._olivier_elemento_by_travis_curry-3.jpg?itok=9K_LJhts)
Landmark AI Project Harnesses Voice to Diagnose Disease, Releases First Data
December 2, 2024
Researchers at USF Health and Weill Cornell Medicine, as part of an expansive, multi-institutional project investigating voice as a biomarker for disease, have reached a significant milestone by publishing the first version of their clinically validated voice dataset to an online artificial intelligence platform where it will be an invaluable resource for researchers across the globe.
![Prostate cancer cells with low levels of PKCλ/ι (turquoise) show increased EZH2 expression (magenta). Credit: Dr. Tania Cid-Diaz Prostate cancer cells with low levels of PKCλ/ι (turquoise) show increased EZH2 expression (magenta). Credit: Dr. Tania Cid-Diaz](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/screenshot_2024-11-20_at_12.04.21_pm.png?itok=297QTe8_)
![Credit: Mittal lab](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/screenshot_2024-11-04_at_11.45.15_am_0.png?itok=4DaqtjD6)
Metabolic Reprogramming of T cells May Enhance Checkpoint Inhibitor Therapy
November 4, 2024
Stimulating a key metabolic pathway in T cells can make them work more effectively against tumors when combined with immune checkpoint inhibitor therapy, according to a preclinical study led by researchers at Weill Cornell Medicine. The findings suggest a potential strategy for enhancing the potency of anticancer immunotherapies.
![Dr. Ekta Khurana](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/khurana27apr2015-sm2_1.jpg?itok=3pWITaMG)
Dr. Ekta Khurana Wins New Starr Cancer Consortium Grant!
October 29, 2024
New Starr Cancer Consortium Grants Awarded to Weill Cornell Medicine Researchers
October 30, 2024
Three teams led by Weill Cornell Medicine scientists have received awards from the Starr Cancer Consortium in its 17th and final annual grant competition. The grants will fund research on the deep mechanisms of common cancers and related treatment strategies.
![A Fully Automated AI-Based System for Assessing IVF Embryo Quality AI-based tool can assist embryologists in determining both the embryo quality score and ploidy status, providing a comprehensive assessment of the embryo. Courtesy of Suraj Rajendran.](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/screenshot_2024-10-23_at_11.22.59_am.png?itok=DoV5vV5n)
A Fully Automated AI-Based System for Assessing IVF Embryo Quality
October 23, 2024
A new artificial intelligence-based system can accurately assess the chromosomal status of in vitro-fertilized (IVF) embryos using only time-lapse video images of the embryos and maternal age, according to a study from investigators at Weill Cornell Medicine.
![Dr. Silvia Formenti](https://eipm.weill.cornell.edu/sites/default/files/styles/medium/public/news_images/wcm_formenti-8_edit_1.png?itok=pgXJjiWy)
EIPM Member Dr. Silvia Formenti Elected to National Academy of Medicine!
October 22, 2024
EIPM Member Dr. Silvia Formenti Elected to National Academy of Medicine!
Dr. Silvia Formenti, chair of the Department of Radiation Oncology and the Sandra and Edward Meyer Professor of Cancer Research at Weill Cornell Medicine has been elected to the National Academy of Medicine.