Englander Institute for Precision Medicine

Spatial Profiling Platform

Tissue and cell heterogeneity remain one of the major challenges in the pursuit of understanding complex diseases and the mechanisms that govern them. The development of multiplex spatial profiling technologies has provided an unprecedented opportunity for clinical, translational, and basic scientists to begin addressing this obstacle, providing new hope for the discovery of novel therapeutic approaches and diagnostic techniques.

Innovative Technology for Research 

While the introduction of groundbreaking technologies has opened many doors, as with any new approach, its novelty can present limitations for investigators. The EIPM Spatial Profiling Platform was developed to be accessible to investigators who are both familiar with the complexity of this new technology and who are new to the field and excited to use cutting-edge techniques to advance their studies.

NanoString CosMx  

Spatial single-cell profiling to elevate research studies.  

The CosMx spatial profiler will power discovery by enhancing our ability to characterize tissue complexity at the single-cell resolution. This technologies explores high-resolution multi-plex RNA and Protein profiling. It offers pre-developed and custom panel profiling of formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF) human and mouse tissue. 

NanoString CosMx™ SMI for Single-Cell Imaging

NanoString CosMx™ SMI for Single-Cell Imaging

  • Subcellular Resolution: CosMx provides high-resoNanostring resolutionlution spatial RNA and protein profiling ofhuman formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF) tissue samples at the cellular and subcellular resolution.
  • Spatial Multi-omics: Use of this technology enables rapid multiplex quantification and visualization of both RNA and protein analytes on serially sectioned tissue. Pre-developed panels include detection of 1,000 RNA and 64 validated proteins, with the option of developing additional custom panels to tailor the analysis to your study.
  • Detection of low expressing and damaged molecules: The high sensitivity of this technology enables the use of archival FFPE tissue and the detection of low expression genes.

NanoString CosMx Workflow 

Nanostring CosMx workflow



CosMX title

10x Visium CytAssist

Spatially map the whole transcriptome.

Whole transcriptome RNA profiling of formalin-fixed paraffin-embedded (FFPE) and fresh frozen (FF) human and mouse tissue.

10x Visium CytAssist

10x Visium CytAssist

10x Visium CytAssist Spatial Gene Expression measures the whole transcriptome of intact fresh frozen (FF) and formalin-fixed paraffin-embedded (FFPE) sections in a spatially resolved manner by mapping gene expression over a high-resolution microscope image of the H&E- or IF-stained tissue.

Protein Co-Detection: Get unbiased spatial gene expression data from your region or cell-type of interest by combining 10x Visium CytAssist whole transcriptome spatial gene expression and a standard IF workflow using your preferred antibodies.

Visium 1

  • Explore transcriptome and protein relationships with simultaneous spatial detection
  • Discover new tissue biomarkers with cell-type specificity


visium workflow



If you are interested in exploring a new translational research collaboration, submit inquires here.

To learn more about Spatial Profiling at the Englander Institute contact

Alicia Alonso, PhD
Associate Research Professor of Molecular Biology
Director of Innovation
Englander Institute of Precision Medicine

Shauna L. Houlihan, PhD ​
Director of Translational Research, Englander Institute for Precision Medicine
Assistant Professor of Research

Weill Cornell Medicine Englander Institute for Precision Medicine 413 E 69th Street
Belfer Research Building
New York, NY 10021