Title | Interferon signaling restrains renal cell carcinoma heterogeneity. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Holicek P, Fucikova J, Galluzzi L |
Journal | Trends Cancer |
Volume | 9 |
Issue | 11 |
Pagination | 871-873 |
Date Published | 2023 Nov |
ISSN | 2405-8025 |
Keywords | Carcinoma, Renal Cell, Humans, Interferon Type I, Kidney Neoplasms, Nucleotidyltransferases, Signal Transduction |
Abstract | Type I interferon (IFN) is central to cancer surveillance as it mediates both direct and immune-mediated oncosuppressive effects. A recent study by Perelli et al. suggests that the ability of renal cancer cells to tolerate complex karyotypic alterations elicited by chromosomal instability (CIN), and ultimately acquire full metastatic potential, is also negatively regulated by IFN signaling. |
DOI | 10.1016/j.trecan.2023.08.008 |
Alternate Journal | Trends Cancer |
PubMed ID | 37658022 |
Grant List | R01 CA271915 / CA / NCI NIH HHS / United States U54 CA274291 / CA / NCI NIH HHS / United States |