Englander Institute for Precision Medicine

Mitochondrial control of antigen presentation in cancer cells.

TitleMitochondrial control of antigen presentation in cancer cells.
Publication TypeJournal Article
Year of Publication2023
AuthorsSoler-Agesta R, Anel A, Galluzzi L
JournalCancer Cell
Volume41
Issue11
Pagination1849-1851
Date Published2023 Nov 13
ISSN1878-3686
KeywordsAntigen Presentation, Histocompatibility Antigens Class I, Humans, Neoplasms, T-Lymphocytes, Cytotoxic
Abstract

Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism.

DOI10.1016/j.ccell.2023.10.001
Alternate JournalCancer Cell
PubMed ID37890494

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