Title | Mitochondrial control of antigen presentation in cancer cells. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Soler-Agesta R, Anel A, Galluzzi L |
Journal | Cancer Cell |
Volume | 41 |
Issue | 11 |
Pagination | 1849-1851 |
Date Published | 2023 Nov 13 |
ISSN | 1878-3686 |
Keywords | Antigen Presentation, Histocompatibility Antigens Class I, Humans, Neoplasms, T-Lymphocytes, Cytotoxic |
Abstract | Cytotoxic T lymphocytes recognize and kill cancer cells when the latter present antigenic epitopes complexed with MHC class I molecules on their surface. In a recent Science paper, Mangalhara et al. show that alterations of the mitochondrial electron flow upregulate multiple factors involved in antigen presentation via a succinate-dependent epigenetic mechanism. |
DOI | 10.1016/j.ccell.2023.10.001 |
Alternate Journal | Cancer Cell |
PubMed ID | 37890494 |