| Title | Adaptive inhibition of CGAS signaling by TREX1. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Lira MCecilia, Vanpouille-Box C, Galluzzi L |
| Journal | Trends Cancer |
| Volume | 10 |
| Issue | 3 |
| Pagination | 177-179 |
| Date Published | 2024 Mar |
| ISSN | 2405-8025 |
| Keywords | Animals, Cytokines, DNA, Exodeoxyribonucleases, Humans, Mammals, Mice, Mice, Knockout, Nucleotidyltransferases, Phosphoproteins |
| Abstract | Mammalian cells react to the accumulation of double-stranded (ds)DNA in the cytosol by secreting antiviral and proinflammatory cytokines, notably type I interferon (IFN). Recent data reported by Tani et al. demonstrate that overactivation of this pathway is prevented by an adaptive feedback mechanism elicited by type I IFN receptors and executed by the exonuclease three prime repair exonuclease 1 (TREX1). |
| DOI | 10.1016/j.trecan.2024.02.001 |
| Alternate Journal | Trends Cancer |
| PubMed ID | 38355355 |
| Grant List | R01 NS131945 / NS / NINDS NIH HHS / United States R21 CA280787 / CA / NCI NIH HHS / United States |