Englander Institute for Precision Medicine

Adaptive inhibition of CGAS signaling by TREX1.

TitleAdaptive inhibition of CGAS signaling by TREX1.
Publication TypeJournal Article
Year of Publication2024
AuthorsLira MCecilia, Vanpouille-Box C, Galluzzi L
JournalTrends Cancer
Date Published2024 Mar
KeywordsAnimals, Cytokines, DNA, Exodeoxyribonucleases, Humans, Mammals, Mice, Mice, Knockout, Nucleotidyltransferases, Phosphoproteins

Mammalian cells react to the accumulation of double-stranded (ds)DNA in the cytosol by secreting antiviral and proinflammatory cytokines, notably type I interferon (IFN). Recent data reported by Tani et al. demonstrate that overactivation of this pathway is prevented by an adaptive feedback mechanism elicited by type I IFN receptors and executed by the exonuclease three prime repair exonuclease 1 (TREX1).

Alternate JournalTrends Cancer
PubMed ID38355355
Grant ListR01 NS131945 / NS / NINDS NIH HHS / United States
R21 CA280787 / CA / NCI NIH HHS / United States

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