Events

“Profiling human tumor-specific T cell responses for cancer biomarker discovery” Presented by Evan Newell, Ph.D. Professor Vaccine and Infectious Disease Division, Fred Hutch Joint Professor, Herbold Computational Biology Program Public Health Sciences Division, Fred Hutch Member Immunotherapy Integrated Research Center (IIRC), Fred Hutch & Pathogen-Associated Malignancies Integrated Research Center (PAM IRC), Fred Hutch Learn more about Dr. Newell... Dr. Evan Newell is an immunologist who develops and employs new technologies for accurately identifying specific biological signatures of human health and disease, including cancer and infectious diseases. He and his team work with blood and tissue samples, using mass cytometry and other single-cell analysis methods to better understand how the specificities of immune T cells influence their roles in clinically productive responses against pathogens or cancers.

“Cancer Epigenetics and Epitranscriptomics; From Knowledge to Applications” Presented by Professor Manel Esteller, M.D., Ph.D. Dr. Esteller is the Director of the Josep Carreras Leukaemia Research Institute (IJC), Chairman of Genetics in the School of Medicine of the University of Barcelona, and an ICREA Research Professor. His current research is devoted to the establishment of the epigenome and epitranscriptome maps of normal and transformed cells, the study of the interactions between epigenetic modifications and non-coding RNAs, and the development of new epigenetic drugs for cancer therapy.

This Month's Topic: “wsPurity - Weakly Supervised Tumor Purity Prediction from H&E Stained Slides” Presented by Salil Maharjan Staff Associate in Computational Biomedicine

Connect. Engage. Learn. Join us on Tuesday July 9th at the Englander Institute for Precision Medicine to learn from your fellow experts and researchers in the CyTOF and Imaging Mass Cytometry™ (IMC™) communities. Discover how high-parameter CyTOF and IMC are transforming clinical research and improving human health. Keynote speaker: Imaging Mass Cytometry uncovers the role of the tumor microenvironment in tumor progression and response to therapy Olivier Elemento, Ph.D. Director of the Caryl and Israel Englander Institute for Precision Medicine Presentations: Spatially phenotyping immune and epithelial cell niches of lung carcinogenesis using IMC. Roxana Pfefferkorn, Ph.D. Senior Postdoctoral Associate at Boston University, Chobanian and Avedisian School of Medicine The landscape of host responses and disease pathology in SARS-CoV-2 infection. Robert Schwartz M.D, Ph.D. Assistant Professor of Medicine Sanford I. Weill Medical College of Cornell University Evaluation of cell types that contribute to the lung aging and small airway disease in COPD via mass cytometry. Anna Blumental-Perry Assistant Professor at the University of Buffalo, Department of Biochemistry Presentation title coming soon. Clinton Hupple, MS Director, Product Line Manager, Imaging at Standard BioTools Unprecedented resolution inside the cell with CyTOF enables novel discovery of the functional diversity of human T cells. Erika Mahoney Ph.D. Candidate at Boston University, Snyder-Cappione Lab World Trade Center Dust-Induced Lung Lymphocytosis and Nascent Fibrosis in Mice with Targeted Deletion of the Vasoactive Intestinal Peptide (VIP) Gene Nicholas Favazza MD/MPH dual degree student at the Zucker School of Medicine at Hofstra/Northwell

Clinical Whole Genome Sequencing & Research Whole Exome Sequencing/RNA Sequencing Results 75-year-old male with metastatic high-grade urothelial carcinoma 59-year-old patient with clear cell adenocarcinoma of the urethra Cases referred by Dr. Cora Sternberg and presented by Dr. Daniela Guevara

AI Working Group Interactive club, open discussions, and presentations related to Artificial Intelligence Research. “Modeling Highly Multiplexed Imaging Data with Self Supervised Deep Learning – Challenges and Approaches” Presented by: Kyle Finos, Medical Student

Anne O’Donnell Luria, M.D., Ph.D. Co-Director of the Center for Mendelian Genomics (CMG) at the Broad Institute of MIT and Harvard Attending Physician in Genetics and Metabolism, Boston Children’s Hospital Assistant Professor, Harvard Medical School Presenting "Navigating the Unknown: Novel Approaches to Rare Disease Diagnosis.”

Englander Institute for Precision Medicine - Journal Club Discussion Article: Nicheformer: a foundation model for single-cell and spatial omics Presented By: Sean Houghton Senior Bioinformatics Analyst Department of Physiology & Biophysics

We leverage patient-derived 3D organoid models from different cancers, which reproduce the oncogenic programs of human tumors, to reveal cellular and molecular mechanisms underlying tumor-intrinsic sensitivity to IFNg. The talk will address: How intratumoral genetic heterogeneity influences sensitivity to IFNg signaling.How intratumoral genetic heterogeneity influences the expression of IFNg-induced and therapeutically relevant immune checkpoints and soluble mediators. Such insights are key to the development of combination treatments targeting immune checkpoint ligands and tumor-specific vulnerabilities.Given the critical role of IFNg in antitumor immunity, we address how tissue-specific and tumor-intrinsic differences must be considered to identify targetable immunophenotypes and underlying molecular cascades that influence IFNg responsivity and ICB efficacy.About Dr. Anna S. Tocheva: My laboratory integrates cellular and molecular immunological assays with high-throughput proteomic and genomic approaches to study the signaling pathways triggered by immune checkpoints in human T cells. In parallel, we develop scalable approaches that incorporate cancer patient-derived organoids with reconstituted immune cells allowing us to translate these fundamental immunobiology discoveries into functional pre-clinical immunoassays to identify mono- and combination immunotherapies that augment anti-tumor T cell responses. — Anna S. Tocheva, Ph.D. Assistant Professor Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai

Englander Institute for Precision Medicine - Journal Club Discussion Article: Towards a general-purpose foundation model for computational pathology Presented By: Mohamed Omar, M.D. Assistant Professor of Research Department of Pathology and Laboratory Medicine Weill Cornell Medicine