Title | A mitochondrial checkpoint to adaptive anticancer immunity. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Kepp O, Liu P, Kroemer G, Galluzzi L |
Journal | Oncoimmunology |
Volume | 12 |
Issue | 1 |
Pagination | 2271693 |
Date Published | 2023 |
ISSN | 2162-402X |
Keywords | Proto-Oncogene Proteins c-bcl-2 |
Abstract | BCL2 robustly preserves mitochondrial integrity, hence inhibiting innate immune signaling and apoptotic cell death in several cell types. Here, we comment on our recent data demonstrating that BCL2 also limits the ability of dendritic cells to elicit adaptive immune responses, lending support to a universal immunosuppressive function for the mitochondrial immune checkpoint. |
DOI | 10.1080/2162402X.2023.2271693 |
Alternate Journal | Oncoimmunology |
PubMed ID | 37860277 |
PubMed Central ID | PMC10583618 |
Grant List | R01 CA271915 / CA / NCI NIH HHS / United States U54 CA274291 / CA / NCI NIH HHS / United States |