EIPM's First Quarter 2025 External NewsletterMemo
March 31, 2025
Dear Friend of the Englander Institute for Precision Medicine,
Welcome to our first quarterly external newsletter of 2025!
Thank you for signing up on our website to receive this newsletter, we hope you enjoy learning more about the important progress we've made towards our mission since the end of 2024. 
On February 11th we recognized the International Day of Women and Girls in Science with a social media campaign on X/Twitter, Facebook, Instagram, Threads, and Bluesky highlighting some of the amazing women who inspire and motivate us every day!
It's been a remarkably productive quarter, with new awards & grants to researchers, new clinical trials initiated, news media coverage of our colleagues, exciting events, and published research in top-tier scientific journals. A sample of this work is highlighted below. 
This important work is only possible because of the financial support we receive from foundations, government agencies, corporate partners, and individual donors. We invite you to consider donating to our mission to advance science and speed new treatments to patients.
Thank you again for your interest in our work!
Sincerely,
Olivier Elemento, Ph.D.
News Coverage & Awards 
On January 14th President Biden announced that our colleague Dr. Ekta Khurana had earned a 2025 Presidential Early Career Award for Scientists and Engineers, the highest honor bestowed by the U.S. government on outstanding scientists and engineers early in their careers.
Congratulations to our colleague Dr. Ravi Sharaf, a gastroenterologist with a special focus on hereditary cancer, on being named in February a Castle Connolly top doctor for 2025!
Congratulations to Dr. Niro Anandasabapathy on her election in March to the American Society for Clinical Investigation!
A recent paper from Nature Communications, "Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease," by Drs. Jan Krumsiek and Dr. Karsten Suhre has been covered in Neuroscience News on March 14th, Technology Networks Neuroscience News and Research on March 17th; the Cornell Chronicle on March 18th, and Science Alert on March 29th.
Dr. Lisa Newman was among the 33 leaders selected on March 10th by the American Association for Cancer Research (AACR) to their newly elected 2025 class of Fellows of the AACR Academy!
Events
On January 16th our colleague Bhavneet Bhinder (right) presented an EIPM Journal Club paper "Lung adenocarcinoma promotion by air pollutants," published in Nature.
Congratulations to Dr. Laura Santambrogio, our Associate Director Precision Immunology, on being named Co-Chair of the 1st Gordon Research Conference on MHC-Restricted Antigen Processing and Presentation, to be held in Texas in February of 2026. Dr. Santambrogio will also be an Invited Speaker for the 2025 Women in Biotech conference in New York. 
Clinical Director Dr. Cora N. Sternberg moderated and presented on bladder cancer therapy at the 40th Annual European Association of Urology meeting in Madrid in March, and is an invited Keynote speaker at the International Kidney Cancer meeting in Amsterdam in May.
If you're heading to the 2025 AACR annual meeting be sure to check out the oral presentation "Morphological evaluation of chromosomal instability in circulating tumor cells and prediction of taxane resistance in metastatic prostate cancer: a prespecified sub-analysis of the CARD trial," co-authored by Clinical Director Dr. Cora N. Sternberg in the Liquid Biopsy: Circulating Tumor Cells session on April 27th at 3:25 pm.
Publications
"IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs," was published in Nature Immunology on January 9th by our former colleague Dr. Akanksha Verma and Director Olivier Elemento, PhD.
"Evaluation of ChatGPT as a Reliable Source of Medical Information on Prostate Cancer for Patients: Global Comparative Survey of Medical Oncologists and Urologists," was published in the January 2025 edition of Urology Practice by our Clinical Director Dr. Cora N. Sternberg with Dr. Andrea Sboner from the Pathology and Laboratory Medicine department and the EIPM, with colleagues. 
"PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+sensor proteins," was published in the Proceedings of the National Academy of Sciences on February 18th by Emily M. Huntsman and former colleague Tomer M. Yaron-Barir.
"Single-cell atlas of human pancreatic islet and acinar endothelial cells in health and diabetes," was published in Nature Communications on February 6th by Dr. Shahin Rafii and WCM colleagues. The paper was also covered by the WCM Newsroom website. 
"Transcriptional activation of regenerative hematopoiesis via microenvironmental sensing," was published in Nature Immunology on February 25th by Dr. Sean Houghton, a postdoc in the lab of our EIPM colleague Dr. Shahin Rafii, Dr. Jenny Z. Xiang, and WCM colleagues.
"Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease. The findings provide evidence that therapeutically enhancing bioenergetic health may reduce the risk of symptomatic AD," was published in Nature Communications on February 24th by our colleagues Drs. Jan Krumsiek and Karsten Suhre. 
"Suppression of endothelial ceramide de novo biosynthesis by Nogo-B contributes to cardiometabolic diseases," was published in Nature Communications on February 25th by Rohan Bareja and Director Olivier Elemento.
"Upregulation of the interferon-inducible antiviral gene RSAD2 in neuroendocrine prostate cancer via PVT1 exon 9 dependent and independent pathways," was published in the Journal of Biological Chemistry on February 28th by Katheryn Gorski and Jyothi Manohar, with Dr. Andrea Sboner from the Pathology and Laboratory Medicine department and the EIPM.
"Exome Sequencing Reveals a Sparse Genomic Landscape in Kaposi Sarcoma," was published in Molecular Cancer Research on March 4th by Dr. Ethel Cesarman from Pathology and Laboratory Medicine and Bhavneet Bhinder and Director Olivier Elemento, Ph.D. 
A new Cornell Chronicle article from March 12th, "Flipping switch boosts stem cell numbers for therapies. A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells. The discovery could lead to more effective bone marrow transplants and gene therapies," recaps recent research in Nature Immunology by Dr. Shahin Rafii and colleagues.
"Predicting response to neoadjuvant chemotherapy in muscle-invasive bladder cancer via interpretable multimodal deep learning," was published in NPJ Digital Medicine by Drs. Bishoy Faltas and Olivier Elemento on March 22nd. The paper was also covered by UroToday on March 25th and OncoDaily on March 31st. 
"A complex phylogeny of lineage plasticity in metastatic castration resistant prostate cancer," was published in Precision Oncology on March 28th by Dr. Juan Miguel Mosquera from the Pathology and Laboratory Medicine department and the EIPM; with EIPM colleagues Drs. Jones T. Nauseef, Alicia Alonso, Iman Hajirasouliha, David M. Nanus, Scott T. Tagawa and Olivier Elemento, and Michael Sigouros and Jyothi Manohar; also with Drs. Brian D. Robinson and Andrea Sboner from the Pathology and Laboratory Medicine department and the EIPM.
"The Bridge2AI-Voice Application: Initial Feasibility Study of Voice Data Acquisition Through Mobile Health Bridge2AI Voice-App: Feasibility Study," was published in Frontiers in Digital Health on March 31st by Alexandros Sigaras and Director Olivier Elemento, Ph.D., with WCM colleagues. 
"A patient-derived T cell lymphoma biorepository uncovers pathogenetic mechanisms and host-related therapeutic vulnerabilities," was published in Cell Reports Medicine on March 26th by Drs. Liron Yoffe, Peter Martin, Associate Director for Precision Immunology Laura Santambrogio, Doron Betel, Director Olivier Elemento, with Dr. Giorgio Inghirami from the Pathology and Laboratory Medicine department and the EIPM.
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