Dear Friend of the Englander Institute for Precision Medicine,
Welcome to our second quarterly external newsletter of 2024!
Thank you for signing up on our website to receive this newsletter, we hope you enjoy learning more about the important progress we've made towards our mission since the end of March. 
Congratulations to our colleague Dr. Bishoy Faltas on being named the EIPM's Chief Research Officer! Dr. Faltas will oversee EIPM's strategic research directions, and develop new programs and partnerships that integrate biology, technology, and clinical advances to revolutionize patient care. 
We recently kicked off our annual Summer Program for high school students! The students will partner with EIPM faculty mentors, work on individual & group projects, attend EIPM events, including seminars, lectures, working groups, and journal clubs, and attend weekly lectures.
It's been a remarkably productive quarter, with new awards & grants to researchers, new clinical trials initiated, news media coverage of our colleagues, exciting events, and published research in top-tier scientific journals. A sample of this work is highlighted below.
This important work is only possible because of the financial support we receive from foundations, government agencies, corporate partners, and individual donors. We invite you to consider donating to our mission to advance science and speed new treatments to patients.
Thank you again for your interest in our work!
Sincerely,
Olivier Elemento, Ph.D.
EIPM Director
News Coverage & Awards 
Please join me in congratulating our colleague Dr. Niroshana Anandasabapathy on earning a new $3.7 million R01 award from the NIH! The title of her award is "New mechanisms governing skin tissue residency memory T cells," which will be used to study how infections and tumors evade early immune detection in barrier tissues such as the skin, lung, and gut.
Dr. Lisa Newman earned the 2024 Gianni Bonadonna Breast Cancer Award from ASCO! The award recognizes an active clinical and/or translational researcher with a distinguished record of accomplishments in advancing the field of breast cancer and with exceptional mentoring abilities. Dr. Newman was also interviewed for the April 16th article "How New Ideas Are Changing Advanced Breast Cancer Research," published in Health Reporter News. 
Clinical Director Dr. Cora N. Sternberg was interviewed for the video news article "Navigating the Shift to Enfortumab Vedotin and Pembrolizumab in Advanced Urothelial Cancer: Key Considerations for Clinicians," that was published by UroToday on April 24th.
EIPM Director Olivier Elemento, Ph.D. spoke on the "Upcoming AI Revolution in Healthcare and Medicine" at the AI Meets Science conference hosted by New York University's Tandon School of Engineering on April 26th.
Alexandros Sigaras and I were featured in a new Summer 2024 Impact Magazine feature article, "The Sounds of Science, marrying acoustic insights from ornithology with artificial intelligence, doctors and researchers at Weill Cornell Medicine hope to use the human voice to screen for disease." The Bridge2AI project is fascinating, and includes partners from the University of South Florida, the NIH, and the Cornell Lab of Ornithology.
Events
On May 6th I was honored to led a delegation from the Indian Council of Medical Research on a tour of our labs and introduce them to staff. Thanks to our colleagues who participated and organized the visit, including Benjamin Hopkins, Jenna Moyer, Ilkay Us, Omar Alawa, Hiranmayi Ravichandran, Amanda Reid, Victoria Cummings and Marie Normile.
Dr. Iman Hajirasouliha spoke at the 2024 Starr Cancer Consortium Retreat at Cold Spring Harbor on May 13th and presented "Weakly-supervised tumor purity prediction from H&E stained slides." At the same retreat Dr. Bishoy Faltas presented "Defining the functional impact of composite mutations in oncogene-driven urothelial cancer using circulating- tumor DNA and single-cell sequencing," on May 14th.
Director Olivier Elemento presented "Genomes, Avatars and Al: The Future of Personalized Medicine," during the MOGAM 40th Anniversary Symposium in Seoul on May 10th.
Dr. Elemento delivered the Keynote, "Genomes, Avatars and AI: The Future of Personalized Medicine," on June 20th at the Scholars in BioMedical Sciences Symposium hosted by the Renaissance School of Medicine at Stony Brook University!
Our new friends Molly Bonakdarpour and Dr. Erandi de Silva (third from left) from the venture capital firm Drive Capital visited us on June 12th for a tour of our facilities and a briefing on our work by members of our faculty, including Dr. Ben Hopkins and myself.
Publications
"How Artificial Intelligence Unravels the Complex Web of Cancer Drug Response," was published on April 8th in Cancer Research by Dr. Olivier Elemento and colleagues.
"Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort," was published on April 10th in PLOS Computational Biology by our colleagues Drs. Yajas Shah, Ravi N. Sharaf, Scott Kulm, Jones T. Nauseef, and Director Olivier Elemento.
"Targeting immunogenic cell stress and death for cancer therapy," was published on April 15th in Nature Reviews Drug Discovery by Dr. Galluzzi and colleagues.
"Inflammation and mitophagy are mitochondrial checkpoints to aging," was published on April 20th in Nature Communications by Dr. Galluzzi and colleagues.
"Cancer cell metabolism and antitumour immunity," was published on April 22nd in Nature Reviews Immunology by Dr. Galluzzi and colleagues.
"Deep and Durable Prostate-specific Antigen Response to Darolutamide with Androgen Deprivation Therapy and Docetaxel, and Association with Clinical Outcomes for Patients with High- or Low-volume Metastatic Hormone-sensitive Prostate Cancer: Analyses of the Randomized Phase 3 ARASENS Study," was published on April 21st in European Urology by Dr. Cora N. Sternberg and colleagues. 
"Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease," was published on April 27th in Alzheimer's Disease and Dementia by Drs. Richa Batra and Jan Krumsiek.
"Mapping genotypes to chromatin accessibility profiles in single cells," was published in Nature on May 8th by Dr. Dan Landau and colleagues. 
"The intrinsic substrate specificity of the human tyrosine kinome," was published in Nature on May 8th by Drs. Tomer M Yaron-Barir, Emily M. Huntsman, Alexander Kerelsky, Daniel M. Cizin, and Benjamin M. Cohen, from the Meyer Cancer Center and the EIPM, with EIPM Director Olivier Elemento, Ph.D.
"Risk of meningomyelocele mediated by the common 22q11.2 deletion," was published in Science on May 2nd by Dr. Dolores J. Lamb and colleagues.
"The ribotoxic stress response drives UV-mediated cell death," was published in Cell on June 5th by Drs. Tomer M. Yaron-Barir and Emily M. Huntsman. 
"Epigenetic and proteomic signatures associate with clonal hematopoiesis expansion rate," was published in Nature Aging on June 4th by Dr. Pinkal Desai and colleagues.
"Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment," was published in Nature Medicine on June 14th by Dr. Dan Landau, with Drs. Nasser Altorki and Ashish Saxena. The paper was covered by Inside Precision Medicine on June 14th and the Cornell Chronicle on June 18th. 
"Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load," was published in Cell Reports on June 25th by Dr. Laura Santambrogio and colleagues.
"Optimization of Fluorescence In Situ Hybridization Protocols in the Era of Precision Medicine," was published in Current Protocols on June 25th by Dr. Juan Miguel Mosquera, with Drs. Sarah Kudman, Alissa Semaan, David C. Wilkes, Majd Al Assaad from the Pathology and Laboratory Medicine Department and the EIPM, our former EIPM colleague Dr. M. Laura Martin, and EIPM Director Olivier Elemento, PhD.
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