Englander Institute for Precision Medicine
The figure shows a stained graft which was retrieved six weeks after islet and reprogrammed vascular endothelial cell (R-VEC) co-transplantation. The white islet, revealed by insulin staining, is vascularized by green blood vessels derived from co-transplanted R-VECs, which are connected to host blood vessels (red). Credit: Dr. Ge Li

Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study led by Weill Cornell Medicine investigators. The new approach, which requires further development and testing, could someday enable the much wider use of islet transplants to cure diabetes.

Islets, found in the pancreas, are clusters of insulin-secreting and other cells enmeshed in tiny, specialized blood vessels. The...

EIPM Members

Two Weill Cornell Medicine physician-scientists, Dr. Niroshana Anandasabapathy and Dr. Rohit Chandwani, have been elected members of the American Society for Clinical Investigation (ASCI) for 2025.

One of the nation’s oldest nonprofit medical honor societies, the ASCI is comprised of more...

Islet-specific endothelial cells (red) form specialized blood vessels that support and nourish pancreatic islets (green). Credit: Dr. Ge Li

The distinct population of endothelial cells that line blood vessels in the insulin-producing “islets” of the human pancreas have been notoriously difficult to study, but Weill Cornell Medicine investigators have now succeeded in comprehensively detailing the unique characteristics of these cells. The resulting atlas advances basic research on the biology of the pancreas and could lead to new treatment strategies for diabetes and other pancreatic diseases.

In the ...