| Title | Decrease of Pro-Angiogenic Monocytes Predicts Clinical Response to Anti-Angiogenic Treatment in Patients with Metastatic Renal Cell Carcinoma. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Oudard S, Benhamouda N, Escudier B, Ravel P, Tran T, Levionnois E, Negrier S, Barthelemy P, Berdah JFrançois, Gross-Goupil M, Sternberg CN, Bono P, Porta C, De Giorgi U, Parikh O, Hawkins R, Highley M, Wilke J, Decker T, Tanchot C, Gey A, Terme M, Tartour E |
| Journal | Cells |
| Volume | 11 |
| Issue | 1 |
| Date Published | 2021 Dec 22 |
| ISSN | 2073-4409 |
| Keywords | Angiogenesis Inhibitors, Animals, Antigens, CD, Carcinoma, Renal Cell, Disease Models, Animal, Humans, Kidney Neoplasms, Mice, Inbred BALB C, Monocytes, Myeloid Cells, Neoplasm Metastasis, Neovascularization, Pathologic, Sunitinib, Treatment Outcome, Vascular Endothelial Growth Factor Receptor-1 |
| Abstract | The modulation of subpopulations of pro-angiogenic monocytes (VEGFR-1CD14 and Tie2CD14) was analyzed in an ancillary study from the prospective PazopanIb versus Sunitinib patient preferenCE Study (PISCES) (NCT01064310), where metastatic renal cell carcinoma (mRCC) patients were treated with two anti-angiogenic drugs, either sunitinib or pazopanib. Blood samples from 86 patients were collected prospectively at baseline (T1), and at 10 weeks (T2) and 20 weeks (T3) after starting anti-angiogenic therapy. Various subpopulations of myeloid cells (monocytes, VEGFR-1CD14 and Tie2CD14 cells) decreased during treatment. When patients were divided into two subgroups with a decrease (defined as a >20% reduction from baseline value) (group 1) or not (group 2) at T3 for VEGFR-1CD14 cells, group 1 patients presented a median PFS and OS of 24 months and 37 months, respectively, compared with a median PFS of 9 months ( = 0.032) and a median OS of 16 months ( = 0.033) in group 2 patients. The reduction in Tie2CD14 at T3 predicted a benefit in OS at 18 months after therapy ( = 0.04). In conclusion, in this prospective clinical trial, a significant decrease in subpopulations of pro-angiogenic monocytes was associated with clinical response to anti-angiogenic drugs in patients with mRCC. |
| DOI | 10.3390/cells11010017 |
| Alternate Journal | Cells |
| PubMed ID | 35011579 |
| PubMed Central ID | PMC8750389 |
| Grant List | 2019 / / Foncer contre le Cancer / 2020 / / SIRIC CARPEM / 2021 / / Labex Immuno-Oncology / |