Englander Institute for Precision Medicine

Publications

Found 51 results
Author Title Type [ Year(Asc)]
Filters: Keyword is Gene Expression Regulation, Neoplastic  [Clear All Filters]
2024
Chen X, Augello MA, Liu D, Lin K, Hakansson A, Sjöström M, Khani F, Deonarine LD, Liu Y, Travascio-Green J et al..  2024.  Canonical androgen response element motifs are tumor suppressive regulatory elements in the prostate.. Nat Commun. 15(1):10675.
Spada S, Galluzzi L.  2024.  Epigenetic regulation of cancer.. Int Rev Cell Mol Biol. 387:xiii-xvii.
Chatterjee SS, Linares JF, Cid-Diaz T, Duran A, Khan MImran K, Osrodek M, Brady NJ, Reina-Campos M, Marzio A, Venkadakrishnan VBalaji et al..  2024.  Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer.. Nat Commun. 15(1):9755.
Liu J, Cao S, Imbach KJ, Gritsenko MA, Lih T-SM, Kyle JE, Yaron-Barir TM, Binder ZA, Li Y, Strunilin I et al..  2024.  Multi-scale signaling and tumor evolution in high-grade gliomas.. Cancer Cell. 42(7):1217-1238.e19.
Sundaram L, Kumar A, Zatzman M, Salcedo A, Ravindra N, Shams S, Louie BH, S Bagdatli T, Myers MA, Sarmashghi S et al..  2024.  Single-cell chromatin accessibility reveals malignant regulatory programs in primary human cancers.. Science. 385(6713):eadk9217.
2023
Li D, Zhan Y, Wang N, Tang F, Lee CJ, Bayshtok G, Moore AR, Wong EWP, Pachai MR, Xie Y et al..  2023.  ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer.. Sci Adv. 9(14):eadc9446.
2022
Xu X, Wang K, Vera O, Verma A, Jasani N, Bok I, Elemento O, Du D, Yu X, Karreth FA.  2022.  Gain of Chromosome 1q Perturbs a Competitive Endogenous RNA Network to Promote Melanoma Metastasis.. Cancer Res. 82(17):3016-3031.
Tang CP, Clark O, Ferrarone JR, Campos C, Lalani AS, Chodera JD, Intlekofer AM, Elemento O, Mellinghoff IK.  2022.  GCN2 kinase activation by ATP-competitive kinase inhibitors.. Nat Chem Biol. 18(2):207-215.
2021
Rivas MA, Durmaz C, Kloetgen A, Chin CR, Chen Z, Bhinder B, Koren A, Viny AD, Scharer CD, Boss JM et al..  2021.  Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes.. Front Immunol. 12:688493.
Montrose DC, Saha S, Foronda M, McNally EM, Chen J, Zhou XKathy, Ha T, Krumsiek J, Buyukozkan M, Verma A et al..  2021.  Exogenous and Endogenous Sources of Serine Contribute to Colon Cancer Metabolism, Growth, and Resistance to 5-Fluorouracil.. Cancer Res. 81(9):2275-2288.
Mukhopadhyay C, Yang C, Xu L, Liu D, Wang Y, Huang D, Deonarine LDayal, Cyrta J, Davicioni E, Sboner A et al..  2021.  G3BP1 inhibits Cul3 to amplify AR signaling and promote prostate cancer.. Nat Commun. 12(1):6662.
Persi E, Wolf YI, Horn D, Ruppin E, Demichelis F, Gatenby RA, Gillies RJ, Koonin EV.  2021.  Mutation-selection balance and compensatory mechanisms in tumour evolution.. Nat Rev Genet. 22(4):251-262.
Shah Y, Verma A, Marderstein AR, White J, Bhinder B, J Medina SGarcia, Elemento O.  2021.  Pan-cancer analysis reveals molecular patterns associated with age.. Cell Rep. 37(10):110100.
Grbesa I, Augello MA, Liu D, McNally DR, Gaffney CD, Huang D, Lin K, Ivenitsky D, Goueli R, Robinson BD et al..  2021.  Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity.. Cell Rep. 36(10):109625.
Rivas MA, Meydan C, Chin CR, Challman MF, Kim D, Bhinder B, Kloetgen A, Viny AD, Teater MR, McNally DR et al..  2021.  Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.. Nat Immunol. 22(2):240-253.
Lan Y, Banks KM, Pan H, Verma N, Dixon GR, Zhou T, Ding B, Elemento O, Chen S, Huangfu D et al..  2021.  Stage-specific regulation of DNA methylation by TET enzymes during human cardiac differentiation.. Cell Rep. 37(10):110095.
Brady NJ, Bagadion AM, Singh R, Conteduca V, Van Emmenis L, Arceci E, Pakula H, Carelli R, Khani F, Bakht M et al..  2021.  Temporal evolution of cellular heterogeneity during the progression to advanced AR-negative prostate cancer.. Nat Commun. 12(1):3372.
2020
Rheinbay E, Nielsen MMuhlig, Abascal F, Wala JA, Shapira O, Tiao G, Hornshøj H, Hess JM, Juul RIstrup, Lin Z et al..  2020.  Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.. Nature. 578(7793):102-111.
Beltran H, Romanel A, Conteduca V, Casiraghi N, Sigouros M, Franceschini GMarco, Orlando F, Fedrizzi T, Ku S-Y, Dann E et al..  2020.  Circulating tumor DNA profile recognizes transformation to castration-resistant neuroendocrine prostate cancer.. J Clin Invest. 130(4):1653-1668.
Sfakianos JP, Daza J, Hu Y, Anastos H, Bryant G, Bareja R, Badani KK, Galsky MD, Elemento O, Faltas BM et al..  2020.  Epithelial plasticity can generate multi-lineage phenotypes in human and murine bladder cancers.. Nat Commun. 11(1):2540.
Shah MA, Enzinger P, Ko AH, Ocean AJ, Philip PAgop, Thakkar PV, Cleveland K, Lu Y, Kortmansky J, Christos PJ et al..  2020.  Multicenter Phase II Study of Cabazitaxel in Advanced Gastroesophageal Cancer: Association of HER2 Expression and M2-Like Tumor-Associated Macrophages with Patient Outcome.. Clin Cancer Res. 26(18):4756-4766.
Melis M, Zhang T, Scognamiglio T, Gudas LJ.  2020.  Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma.. Carcinogenesis. 41(11):1553-1564.
Fragliasso V, Verma A, Manzotti G, Tameni A, Bareja R, Heavican TB, Iqbal J, Wang R, Fiore D, Mularoni V et al..  2020.  The novel lncRNA BlackMamba controls the neoplastic phenotype of ALK anaplastic large cell lymphoma by regulating the DNA helicase HELLS.. Leukemia. 34(11):2964-2980.
Cyrta J, Augspach A, De Filippo MRosaria, Prandi D, Thienger P, Benelli M, Cooley V, Bareja R, Wilkes D, Chae S-S et al..  2020.  Role of specialized composition of SWI/SNF complexes in prostate cancer lineage plasticity.. Nat Commun. 11(1):5549.
2019
Lee RS, Zhang L, Berger A, Lawrence MG, Song J, Niranjan B, Davies RG, Lister NL, Sandhu SK, Rubin MA et al..  2019.  Characterization of the ERG-regulated Kinome in Prostate Cancer Identifies TNIK as a Potential Therapeutic Target.. Neoplasia. 21(4):389-400.