Dear Friends & Members of the Englander Institute,
We hope you enjoy the new video, "A Conversation with Dr. Benjamin Hopkins," EIPM's Director of Ex Vivo Models, where he discusses a new paper, his research into immunology with organoids that focuses, in part, on colorectal cancer, ovarian cancer, breast cancer, melanoma, lung cancer, and improving immune responses in patients!
We hope you'll join us for an EIPM AI Clinic and learn about applying Large Language Models to data analysis (Claude Opus 4.6, GPT5.2, and Gemini 3.0 Pro), coding challenges, manuscript writing, and exploring how AI tools can securely optimize research and workflows. All skill levels are welcome at our bi-weekly Clinics on Wednesdays at 2 PM. Check our EIPM X/Twitter account for the latest information.
Thank you again for your continued hard work and dedication to our mission.
Sincerely,
Olivier Elemento, Ph.D.
News Coverage & Awards
Please join us in congratulating our colleague Dr. Ekta Khurana on earning a two-year, $1 million Challenge Award from the Prostate Cancer Foundation to work with researchers from Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center on an AI-based method for early detection of treatment-resistant prostate tumor subtypes!
Congratulations to our Chief Research Officer Dr. Bishoy Faltas on having his Nature paper, "The interplay between mutagenesis and extrachromosomal DNA shapes urothelial cancer evolution," earn the 2026 EAU Best Paper on Fundamental Research Award, which was presented on March 14th at the 41st EAU Annual Congress in London!
Our colleague Dr. Scott T. Tagawa scored a GU Oncology Now hat trick on March 6th with the articles, "What CTCAE v6 Means for Defining Dose‑Limiting Toxicity in Modern Clinical Trials," "Linking PSMA PET SUVmax to Genomic Classifier Risk in Treatment‑Naive Prostate Cancer," and "Understanding Patient‑Reported Outcomes With Fractionated and Repeated 225Ac‑J591 Therapy." Dr. Tagawa also produced a video for The Oncology Learning Network entitled Theranostics Advances in Solid Tumors," on March 19th.
Our Clinical Director Dr. Cora N. Sternberg was interviewed by Cure Today for a March 19th feature article, "Evolving Treatment Strategies Are Reshaping mCRPC Care."
Our EIPM colleague Dr. Richard Furman spoke about "Immature Data Limit Conclusions on Continuous vs Fixed-Duration Frontline CLL Therapies," with The Oncology Learning Network on March 19th.
Events
Our latest Precision Medicine Research Conference on March 19th featured a a fascinating presentation by our colleague Dr. Eda Nur Kozan entitled, "The Array of NRG1 Alterations in a Pan-Cancer Cohort: An Integrative Whole-Genome and Transcriptome Analysis." Dr. Jesus Delgado De La Mora from the Pathology and Laboratory Medicine department also presented "Changing Liver Tumor Paradigms: Characterization of NIPBL::NACC1 Fusion Carcinoma," at the same event.
Our Chief Research Officer Dr. Bishoy Faltas presented "Mutational Processes and Extrachromosomal DNA: Engines of Cancer Evolution," at NYU Langone's 2026 Tung-Tien (Henry) Sun Lectureship on March 25th.
Publications
"Radiographic Progression With and Without Prostate-Specific Antigen Rise in Patients With Advanced Prostate Cancer Treated With Enzalutamide," was published in The Journal of Clinical Oncology on March 27th by Clinical Director Dr. Cora N. Sternberg. And Dr. Sternberg also published "Molecular Landscape of Prostate Cancers with Clival Metastases," was published in The Oncologist on March 4th with Dr. Emily Weg.
A recent Nature Communications paper, "FOXJ1 mediates taxane resistance through regulation of microtubule dynamics," by EIPM Member Dr. Paraskevi Giannakakou was featured in a WCM Newsroom article on March 10th. 
"Dual-positive CTCs in patients with advanced breast cancer show metastatic potential and prognostic value," was published in Science Translational Medicine on March 11th by our Scientific Director Dr. Massimo Cristofanilli and Dr. Carolina Reduzzi. This paper was also featured in a WCM Newsroom article on March 11th.
"Diagnosis of Polycystic Ovary Syndrome With Predictive Modeling of Select Clinical Features. The objective of this research is to determine whether a limited set of ultrasonographic, biochemical, and clinical features are sufficient to accurately predict polycystic ovary syndrome (PCOS) diagnosis," was published in OG Open on March 19th by Dr. Iman Hajirasouliha.
"Lipidomic profiling in metastatic prostate cancer captures tumor metabolic rewiring and its modulation by androgen receptor–targeting therapy," was published in Prostate Cancer and Prostatic Diseases on March 13th by Dr. Massimo Loda, Chair of the Pathology and Laboratory Medicine department, and our EIPM colleague Dr. David Nanus.
"19q13 amplification with AKT2 and ERCC2 gains in sarcomatoid carcinoma of the urinary bladder," was published in Cancer Genetics on March 10th by our Chief Research Officer Dr. Bishoy Faltas, with Drs. Ana Molina, Olivier Elemento and Juan Miguel Mosquera from the Pathology and Laboratory Medicine department and the EIPM. 
"Machine learning analysis of population-wide plasma proteins identifies hormonal biomarkers of Parkinson’s disease," was published in Frontiers in Aging Neuroscience on March 9th by Director Olivier Elemento, Ph.D. and WCM colleagues. 
"Characterizing Human Oxidative, Anabolic and Glycolytic Metabolism in Athletes with Extreme Physiologies," was published in Sports Medicine Open on March 9th by Dr. Jan Krumsiek and colleagues.
"Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors," was published in iScience on March 20th by Drs. Benjamin D. Hopkins, Olivier Elemento and colleagues. 
"Trabectedin decreases myeloid resistance to improve the efficacy of anti-PD1 immunotherapy and delay glioma malignant progression," was published in Molecular Therapy Oncology on March 19th by Drs. Bhavneet Bhinder and Olivier Elemento.
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