Dear Friends & Members of the Englander Institute,
Welcome to fourth quarterly external newsletter of 2025!
Thank you for signing up on our website to receive this newsletter, we hope you enjoy learning more about the important progress we've made towards our mission since the end of September.
Since we know you love science, medicine & technology, why not follow us daily on our social media channels and never miss our news, events, awards, and publications: on X/Twitter, Facebook, Instagram, Threads, and Bluesky!
It's been a remarkably productive quarter, with new awards & grants to researchers, new clinical trials initiated, news media coverage of our colleagues, exciting events, and published research in top-tier scientific journals. A sample of this work is highlighted below. 
This important work is only possible because of the financial support we receive from foundations, government agencies, corporate partners, and individual donors. We invite you to consider donating to our mission to advance science and speed new treatments to patients.
Thank you again for your interest in our work!
Sincerely,
Olivier Elemento, Ph.D.
News Coverage & Awards 
"Health Data Marketplace - Challenges, Possibilities, and the Path Forward: ConV2X Decentralized Health Event Podcast," a new Blockchain in Healthcare Today podcast featuring Dr. Olivier Elemento, with experts from Accrete.ai and Nav.AI., broadcast on December 6th.
"Why Medical Schools Need Dedicated AI Departments. A Department of AI would provide methods expertise from bench to bedside. And it can contribute directly to clinical operations and revenue, not just research. Academic medical centers have clinical data and domain expertise that industry lacks." OncoDaily opinion article by our Director, Olivier Elemento, Ph.D., December 19th.
Director Olivier Elemento, Ph.D. received a Clarivate 2025 Highly Cited Researcher Award on November 11th! 
"Research at Risk: Rooting Out Treatment-Resistant Prostate Cancer," a Weill Cornell Medicine Newsroom article from October 7th, profiles the prostate cancer research of our colleague Dr. Ekta Khurana and her $1.2 million DoD grant, which was paused in April when the federal government suddenly ordered her to stop, threatening the progress she’s made as well as the careers of the researchers working with her.
Please join us in congratulating our Clinical Director Dr. Cora N. Sternberg on being named to Research.com's 2025 list of the Top 1000 Female Scientists! She's ranked #305 in the U.S., and #516 in the world! And in the Commentary "Considering the Evolution of ARPI Combination Therapy in mHSPC," Dr. Sternberg discussed the development of androgen receptor pathway inhibitors and takeaways from the ARANOTE trial in hormone-sensitive prostate cancer with Targeted Oncology on October 28th. 
“Breast cancer disparities research is essential in achieving health equity, and it is also an imperative in identifying the root causes as well as optimized treatment for this disease," said Dr. Lisa Newman in a Breast Cancer Awareness Month-timed Sports Illustrated interview on October 22nd. Dr. Newman was interviewed for a similar article, "Shoes for a Cure Kicks Off Big Week in New York With Intimate Saks Cocktail. Ahead of its charity sale at Chelsea Market, the group brought footwear and fashion forces together," which appeared in Women's Wear Daily on October 22nd.
Congratulations to our Clinical Director Dr. Cora N. Sternberg on being awarded the title of Faculty Member of the College of the European School of Oncology for the year 2025, in appreciation for her constant contribution to activities organized by the European School of Oncology!
Please join us in congratulating internationally recognized medical oncologist Dr. Allyson J. Ocean on being named the EIPM's new Director of the Early Onset Gastrointestinal Cancer Program!
Events
We recently profiled our Director of Ex Vivo Models, Dr. Ben Hopkins, to explain how his team builds organoid models of tumors to test different therapeutics, aiming to find new treatments and improve patient care. The overarching goal is to translate research findings into the clinic to benefit patients. We hope you enjoy the interview!
We are excited to announce the upcoming launch of the AI Clinic, hosted by EIPM. These bi-weekly one-hour sessions will be held in-person (either in the WGC ICB Conference Room or Belfer 1401, depending on availability) to enhance how we use LLMs for complex tasks, including coding. They will serve as a collaborative space for hands-on troubleshooting, knowledge sharing, and continuous learning. This clinic is designed for our entire scientific and clinical community, with a special emphasis on trainees (students, postdocs, residents and fellows). It is the perfect forum for Researchers & Scientists, Clinicians and Trainees.
On November 12th we provided a tour of our labs, meeting with staff, and briefing about our important work for representatives from the offices of U.S. Senators, U.S. House of Representatives, N.Y. State Senators & Assembly people, and the NYC Council.
Dr. Andrea Sboner from the Pathology and Laboratory Medicine department and EIPM's Director of Informatics and Computational Biology presented at the Association for Molecular Pathology's annual meeting on Saturday, November 15th during the "Meet the Authors: AMP Clinical Bioinformatician Body of Knowledge Series," session about findings from his recent Journal of Molecular Diagnostics paper describing the roles and activities of a clinical bioinformatician.
Dr. Iman Hajirasouliha delivered the keynote address, "Artificial Intelligence and Foundation Models for Reproductive Medicine: From Embryo to Ovary," during the AI for Biology and Medicine conference on October 30th at the University of North Texas.
Publications
"Resolving the mysteries of brain clearance and immune surveillance," was published in Neuron, a Cell Press journal, on December 3rd by our Associate Director for Precision Immunology Dr. Laura Santambrogio.
"Elevated Salivary Theobromine and Long-Term Improvement of Periodontal Health in Two Cohort Studies. The results were successfully replicated in the SHIP-START data and extended to a lower clinical attachment loss." The Journal of Clinical Periodontology by Dr. Karsten Suhre on December 12th.
"Standardized metrics for assessment and reproducibility of imaging-based spatial transcriptomics datasets. The authors establish best practices and metrics to evaluate and integrate imaging-based multi-omics data from single cells into spatial transcriptomics to spatial proteomics." Published in Nature Biotechnology by our colleagues Drs. Roberto De Gregorio, our Director of Innovation Alicia Alonso and Shauna Lee Houlihan on December 3rd.
"Quantitative HER2 profiling on circulating tumor cells using an EpCAM-independent platform in metastatic breast cancer," was published in Cancer Cell International on December 24th by our EIPM colleagues, including Jyothi Manohar, MPH, Director Olivier Elemento, Ph.D., Eleni Andreopoulou, M.D., Scientific Director Massimo Cristofanilli, M.D., and Carolina Reduzzi, Ph.D. 
"Integrative Metabolomics of Targeted and Non-Targeted Analyses in T2D Progression," was published in Diabetes Care on December 3rd by Dr. Karsten Suhre.
A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes," was published in Nature Immunology on November 28th by our Associate Director for Precision Immunology Dr. Laura Santambrogio.
"Evaluation of Event-Free Survival as a Surrogate Endpoint for Overall Survival in Muscle-Invasive Bladder Cancer Following Neoadjuvant Treatment: A Systematic Review and Meta-Analysis," was published in Oncology and Therapy on November 4th by Clinical Director Dr. Cora N. Sternberg and colleagues.
"Chromosomal instability in circulating tumor cells and cabazitaxel resistance in metastatic castration-resistant prostate cancer," was published in JCI Insight on November 4th by Clinical Director Dr. Cora N. Sternberg and colleagues. 
"Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery," was published in iScience on November 21st by Hiranmayi Ravichandran and colleagues.
"Passenger mutations link cellular origin and transcriptional identity in human lung adenocarcinomas," was published in Nature Genetics on November 27th by Dr. Juan Miguel Mosquera from the Pathology and Laboratory Medicine department and the EIPM. 
"NSD2 targeting reverses plasticity and drug resistance in prostate cancer," was published in Nature on November 26th by Dr. Brian D. Robinson from the Pathology and Laboratory Medicine department and the EIPM.
"Thrombospondin-1–CD47 signaling contributes to the development of T cell exhaustion in cancer," was published in Nature Immunology on November 17th by Dr. Niroshana Anandasabapathy
"MRD-driven Initial Therapy of Acalabrutinib and Lenalidomide plus Rituximab (ALR) or Obinutuzumab (ALO) for Mantle Cell Lymphoma," was published in Blood Advances on November 25th by our EIPM colleagues Bhavneet Bhinder, Jenny Z. Xiang, Michael Sigouros, Olivier Elemento, John P. Leonard, Peter Martin, and Dr. Giorgio Inghirami from the Pathology and Laboratory Medicine department and the EIPM. "Epigenetic regulation of chromosomal instability by EZH2 methyltransferase," was published in Cancer Discovery on October 2nd by Dr. Vivek Mittal, with Drs. Ashley Laughney and Olivier Elemento, and Liron Yoffe, Marvel Tranquille, and Bhavneet Bhinder. This research was also highlighted in a WCM Newsroom article, "Study Finds Restoring Order to Dividing Cancer Cells May Prevent Metastasis," on October 3rd.
"Co-mapping clonal and transcriptional heterogeneity in somatic evolution via GoT-Multi," was published in Cell Genomics on October 10th by Dr. Anna S. Nam from the Pathology and Laboratory Medicine department and the EIPM with our colleague Dr. Richard R. Furman. The paper was covered by the WCM Newsroom and Medical Life Sciences News. 
"Evaluating surrogates for overall survival in the adjuvant treatment of bladder cancer with chemotherapy," was published in the October 13th edition of Urologic Oncology: Seminars and Original Investigations by Clinical Director Dr. Cora N. Sternberg and colleagues.
"A non-canonical aryl hydrocarbon receptor pathway authorizes and safeguards clinical-scale expansion of functional human endothelial cells," was published in Nature Cardiovascular Research on October 14th by Dr. Shahin Rafii and colleagues, and covered by BioEngineer on October 14th.
"Diffuse midline glioma with extra central nervous system metastases in the pediatric, adolescent, and young adult population," was published in Child's Nervous System on October 7th by Dr. Jeffrey P. Greenfield.
"Integration of elemental imaging and spatial transcriptomic profiling for proof-of-concept metals-based pathway analysis of colon tumor microenvironment," was published in Metallomics on October 3rd by Dr. Vivek Mittal.
"Secretory kinase FAM20C triggers adipocyte dysfunction inciting insulin resistance and inflammation in obesity," was published in The Journal of Clinical Investigation on October 28th by Director Olivier Elemento, Ph.D. andBhavneet Bhinder.
"Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery," was published in iScienceon October 31st by Hiranmayi Ravichandran.
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