Englander Institute for Precision Medicine

May 2024 EIPM Director's Monthly Newsletter

News from EIPM Director Olivier Elemento, Ph.D.

Dear Members of the Englander Institute,

Thank you all for a very productive April!

Please join me in congratulating our colleague Dr.Niroshana Anandasabapathy on earning a new R01 award from the NIH! The title of her award is "New mechanisms governing skin tissue residency memory T cells." Additional information below. 

Congratulations to Dr. Bishoy Faltas on being named the EIPM's Chief Research Officer, effective immediately! In this new capacity, Dr. Faltas will oversee EIPM's strategic research directions, and develop new programs and partnerships that integrate biology, technology, and clinical advances to revolutionize patient care. Dr. Faltas has also been promoted to Associate Professor!

Dr. Lisa Newman earned the 2024 Gianni Bonadonna Breast Cancer Award from ASCO! The award recognizes an active clinical and/or translational researcher with a distinguished record of accomplishments in advancing the field of breast cancer and with exceptional mentoring abilities. 

Please help spread the word: Clinical Director Dr. Cora N. Sternberg is recruiting people aged 50 and older, with no active cancer in the last 3 years, to participate, at no cost, in the Grail Pathfinder study for early-detection of cancer, which was recently featured in The Wall Street Journal. For more information about the study please email: grailstudy@med.cornell.edu

I hope you enjoy reading about our April accomplishments, including new awards, media coverage of our work, participation in major conferences & meetings, and impressive publications by a range of EIPM colleagues--including four new papers by Dr. Lorenzo Galluzzi!

Thank you again for your continued hard work and dedication to our mission.

Sincerely,

Olivier Elemento, Ph.D.

News Coverage & Awards 
Dr. Niroshana Anandasabapathy's new $3.7 million award from the NIH will be used to study how infections and tumors evade early immune detection in barrier tissues such as the skin, lung, and gut. The application offers "foundational insight into how tissue-specific immunity is generated and maintained. There is a current urgent need, given the SARSCoV2 pandemic (lung) and Monkeypox (skin) outbreak. Mechanisms being investigated in this application are central to modeling better vaccine immunizations, to understanding the efficacy and toxicity from immune based drugs being used in patients, to generating better adoptive cell therapies, and to therapeutically limit autoimmunity."

Dr. Olivier Elemento was interviewed for the article, "Nightingale Health to open U.S. lab, collaborate with Englander Institute for Precision Medicine at Weill Cornell," that was published on April 17th in LabPulse.com

News of Dr. Bishoy Faltas' promotion to Chief Research Officer was covered by OncoDaily on April 3rd. He also published Expert Commentary, "The Clinical Impact of Delaying Radical Cystectomy in Muscle Invasive BladderCancer," in UroToday on April 10th. 

Dr. Pashtoon Kasi was interviewed for the video news article, "Dr. Kasi on the Use of ctDNA to Help Inform Adjuvant Treatment Decisions in CRC," published on April 12th in OncLiveDr. Kasi was also interviewed for the article "Monitoring ctDNA Predicts HER2+ Cancer Treatment Response," that appeared in Medscape on April 15th. 

At the 2024 Great Debates & Updates in Hematological Malignancies meeting in New York, Dr. Peter Martin, argued in an Oncology Learning Network article on April 6th in favor of alternative treatment regimens over CAR T-cell therapy for follicular lymphoma, highlighting 3 managements.  

"How New Ideas Are Changing Advanced Breast Cancer Research," was published on April 16th in Health Reporter News and featured an extensive interview with Dr. Lisa Newman

Dr. Allyson Ocean was interviewed for the article "I’m a doctor — here’s what to know about rising cancer rates in young people," that was published in The New York Post on April 18th. 

Dr. Manish Shah was interviewed for the article, "Dr. Shah on 5-Year Outcomes with Pembrolizumab/ Chemo in Esophageal Cancer," that was published in OncLive on April 5th. 

Clinical Director Dr. Cora N. Sternberg was interviewed for the video news article "Navigating the Shift to Enfortumab Vedotin and Pembrolizumab in Advanced Urothelial Cancer: Key Considerations for Clinicians," that was published by UroToday on April 24th. 

"Dr. Tagawa on the Rationale for Investigating First-Line Nivolumab Plus Cisplatin in Urothelial Cancer," was published in OncLive on April 17th and featured an interview with our colleague Dr. Scott T. Tagawa

Events
EIPM Director Olivier Elemento, Ph.D. spoke on the "Upcoming AI Revolution in Healthcare and Medicine" at the AI Meets Science conference hosted by New York University's Tandon School of Engineering on April 26th.

Dr. Bishoy Faltas was interviewed by patient advocate Rick Bangs, host of the Bladder Cancer Matters podcast Bladder Cancer US on "AI's Promise in Bladder Cancer Care," available at on Apple Podcasts. Dr. Faltas also presented "Molecular Biomarkers in Bladder Cancer," and" Artificial Intelligence Applications in Bladder Cancer Medicine," at the Bladder Cancer Canada symposium on April 12th. 

Dr. Pashtoon Kasi chaired the session, “Biomarkers Predictive of Therapeutic Benefit” on April 7th at the AACR Annual Meeting in San Diego. 

Dr. Jenny Xiang presented "PacBio HiFi sequencing at the Genomics Resources Core Facility," on April 16th during PacBio's seminar at Weill Cornell Medicine and hosted by the Genomics Resources Core Facilities.

Publications
"How Artificial Intelligence Unravels the Complex Web of Cancer Drug Response," was published on April 8th in Cancer Research by Dr. Olivier Elemento. 

"Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort," was published on April 10th in PLOS Computational Biology by our colleagues Drs. Yajas ShahRavi N. SharafScott Kulm, Jones T. Nauseef, and Director Olivier Elemento.

"Immunological aspects of central neurodegeneration," was published on April 9th in Cell Discovery by Dr. Lorenzo Galluzzi and colleagues. 

"Targeting immunogenic cell stress and death for cancer therapy," was published on April 15th in Nature Reviews Drug Discovery by Dr. Galluzzi and colleagues.

"Inflammation and mitophagy are mitochondrial checkpoints to aging," was published on April 20th in Nature Communications by Dr. Galluzzi and colleagues.

"Cancer cell metabolism and antitumour immunity," was published on April 22nd in Nature Reviews Immunology by Dr. Galluzzi and colleagues. 

"Immune-based Therapies for Penile Cancer," was published on April 16th in Urologic Clinics of North America by Dr. Majd Al Assaad from WCM's Pathology and Laboratory Medicine department and the EIPM, with colleagues. 

"MGMT ProFWise: Unlocking a New Application for Combined Feature Selection and the Rank-Based Weighting Method to Link MGMT Methylation Status to Serum Protein Expression in Patients with Glioblastoma," was published on April 6th in the International Journal of Molecular Sciences by Drs. Yajas Shah and Olivier Elemento

"Deep and Durable Prostate-specific Antigen Response to Darolutamide with Androgen Deprivation Therapy and Docetaxel, and Association with Clinical Outcomes for Patients with High- or Low-volume Metastatic Hormone-sensitive Prostate Cancer: Analyses of the Randomized Phase 3 ARASENS Study." Published on April 21st in European Urology by Dr. Cora N. Sternberg and colleagues.  

"Metabolomics profiling reveals distinct, sex-specific signatures in serum and brain metabolomes in mouse models of Alzheimer's disease," was published on April 27th in Alzheimer's Disease and Dementia by Drs. Richa Batra and Jan Krumsiek

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