Englander Institute for Precision Medicine

September 2025 EIPM Director's Memo

News from the EIPM!

Dear Friends & Members of the Englander Institute,

I hope you enjoy reading about our recent departmental accomplishments, including news media coverage of our work, interesting & engaging departmental events, and impressive publications in top-tier journals like Nature Biotechnology.

We are looking for EIPM Journal Club speakers for November 6 & 13 and December 4 & 11th. Presentations are both in-person and via Zoom, from 3-4 PM, in either Belfer 1401 or Greenberg Y1301. Journal Club topics can vary, including but not limited to: precision medicine, genetics, artificial intelligence in medicine, among other hot button issues in top tier journals. We are open to all ideas to promote lively discussions with varying viewpoints--rather than a simple summary of the paper. Please contact Bhavneet Bhinder or Suzanne Jlelaty to discuss. 

Thank you again for your continued hard work and dedication to our mission.

Sincerely,
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Olivier Elemento, Ph.D.


News Coverage & Awards 
ImageDr. Peter Martin was featured in a new Cancer Network opinion video on August 21st discussing the shifting paradigm for treating fit, transplant-eligible patients with mantle cell lymphoma.

Dr. Allyson Ocean participated in a recent Survivor Net article on the challenges of treating patients with pancreatic cancer, like ‘Bachelorette’ Star Hannah Brown. 

ImageI'd like to share a STAT News opinion article that I published this week with our Clinical Director Dr. Cora N. Sternberg and Dr. Sean Khozin who is the CEO of the CEO Roundtable on Cancer and a former FDA official, entitled "Why Silicon Valley should demand clinical trials for its medical AI. Well-designed prospective clinical trials are the ultimate de-risking strategy." I hope you enjoy the piece. 

OncoDaily published a series of blog posts by Director Olivier Elemento, PhD: "A New Paradigm for Data Interaction – Combining Voice and Augmented Reality," was published on August 25th; "Blurring the Line Between Druggable and Undruggable with AI Tools," on August 22nd; "A Blueprint for AI Benchmarks in Cancer Research," on August 17th; "Another Fantastic Englander Institute/Meyer Cancer Center Summer Program!" on August 16th; "Accelerating Innovation with Safe and Effective Guardrails," on August 10th; "A New Language for Predictive Simulations," on August 8th; and "AI-Designed Genome Editors Are Here," on August 4th. 

ImageDr. Elemento also published the Human-in-the-loop Substack articles: "From Clinic to Code: A Strategic AI Checklist," on August 12th; and "AI Governance: The Accelerator, Not the Anchor," on August 10th.

Our Chief Research Officer Dr. Bishoy Morris Faltas published the OncoDaily blog post "Paired Plus-Minus Sequencing for Accurate Dual-Strand DNA Analysis," on August 15th.


Events
ImageCongratulations to our 2025 Summer Internship program participants who concluded the summer program by presenting their projects Lon August 14th! We thank all of our students for their hard work and dedication to the program, and recognize the EIPM and Meyer Cancer Center mentors and staff who contributed so generously of their time to make this another wonderful summer.

ImageAssistant Professor Dr. Daniela Sia from the Division of Liver Diseases in the Department of Medicine at Icahn School of Medicine at Mount Sinai delivered the EIPM Precision Medicine Seminar Series talk "Discovery of Novel Therapeutic Vulnerabilities in Cholangiocarcinoma," on August 7th then toured our labs with Drs. Benjamin Hopkins and Andrea Sboner.


Publications
Image"Informatics Powering Data to Shape the Future of Molecular Pathology," was published as an Editorial in the August 2025 edition of The Journal of Molecular Diagnostics by Dr. Andrea Sboner from the Pathology and Laboratory Medicine department and the EIPM.

ImageThe preprint "Paired plus-minus sequencing is an ultra-high throughput and accurate method for dual strand sequencing of DNA molecules," was published in bioRxiv on August 14th by our Chief Research Officer Dr. Bishoy M. Faltas, with EIPM colleagues Drs. David Wilkes, Olivier Elemento, Nasser K. Altorki, and Ashish Saxena; and Michael Sigouros, Jyothi Manohar, Abigail King, and John Otilano; along with Drs. Majd Al Assaad and Juan Miguel Mosquera the Pathology and Laboratory Medicine department and the EIPM. 

Image"Redefining druggable targets with artificial intelligence. We highlight the failure of current target taxonomies and the need for benchmarking datasets, and re-evaluate clinical validation for novel AI-driven modalities." Nature Biotechnology commentary by EIPM Director Olivier Elemento, Ph.D., August 19th.

Image"Evaluating surrogates for overall survival in the adjuvant treatment of bladder cancer with chemotherapy," was published in Urologic Oncology: Seminars and Original Investigations by our Clinical Director Dr. Cora N. Sternberg and colleagues, August 21st.

Image"Artificial Intelligence in Hematology," was published in Blood by Director Olivier Elemento, Ph.D. and colleagues on August 22nd. The paper was also previewed in an OncoDaily Insight blog post by Dr. Elemento on August 24th. 

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