Englander Institute for Precision Medicine
A colorized image of adult mobilized blood stem cells (small and roundish) into which Fli-1 modified mRNA has been introduced, expanding on top of engineered vascular endothelial cells.

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to more effective bone marrow transplants and gene therapies.

A colorized image of adult mobilized blood stem cells (small and roundish) into which Fli-1 modified mRNA has been...

EIPM & MCC Summer Internship Program

Dear Members of the Englander Institute,

The figure shows a stained graft which was retrieved six weeks after islet and reprogrammed vascular endothelial cell (R-VEC) co-transplantation. The white islet, revealed by insulin staining, is vascularized by green blood vessels derived from co-transplanted R-VECs, which are connected to host blood vessels (red). Credit: Dr. Ge Li

Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study led by Weill Cornell Medicine investigators. The new approach, which requires further development and testing, could someday enable the much wider use of islet transplants to cure diabetes.

Islets, found in the pancreas, are clusters of insulin-secreting and other cells enmeshed in tiny, specialized blood vessels. The...