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October 4, 2024

Dear Friend of the Englander Institute for Precision Medicine,

Welcome to our third quarterly external newsletter of 2024!

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Spatial molecular profiling of a resected pancreatic adenocarcinoma. Fluorescently-labeled probes bind to RNA targets to identify the location of different cell types within a tumor sample. Credit: Jiwoon Park and Rohit Chandwani

A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead to less invasiveness and weaker biological activity, according to a multicenter study conducted at Weill Cornell Medicine, ...

Transcription factors are proteins (red, green and dark blue subunits) that control when, where and the degree to which genes are expressed. They bind to specific sequences of DNA (gray and light blue helix) and control the transcription of DNA into mRNA, which is used to build proteins. Credit: Shutterstock