| Title | Where are we going with gene screening for male infertility? |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Thirumavalavan N, J Gabrielsen S, Lamb DJ |
| Journal | Fertil Steril |
| Volume | 111 |
| Issue | 5 |
| Pagination | 842-850 |
| Date Published | 2019 May |
| ISSN | 1556-5653 |
| Keywords | Chromosome Deletion, Chromosomes, Human, Y, Genetic Testing, Humans, Infertility, Male, Karyotyping, Male, Protein Array Analysis, Sex Chromosome Aberrations, Sex Chromosome Disorders of Sex Development |
| Abstract | Male infertility is a heterogenous disease process requiring the proper functioning and interaction of thousands of genes. Given the number of genes involved, it is thought that genetic causes contribute to most cases of infertility. Identifying these causes, however, is challenging. Infertility is associated with negative health outcomes, such as cancer, highlighting the need to further understand the genetic underpinnings of this condition. This paper describes the genetic and genomic tests currently available to identify the etiology of male infertility and then will discuss emerging technologies that may facilitate diagnosis and treatment of in the future. |
| DOI | 10.1016/j.fertnstert.2019.03.036 |
| Alternate Journal | Fertil Steril |
| PubMed ID | 31029238 |
| Grant List | R01 DK078121 / DK / NIDDK NIH HHS / United States |