| Title | Spatial-Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment. |
| Publication Type | Journal Article |
| Year of Publication | 2025 |
| Authors | Lv W, Zeng Y, Li C, Liang Y, Tao H, Zhu Y, Sui X, Li Y, Jiang S, Gao Q, Rodriguez-Fos E, Prasad G, Wang Y, Zhou R, Xu Z, Pan X, Chen L, Xiang X, Teng H, Sun C, Qin T, Dong W, Li Y, Lan X, Li X, Lin L, Bolund L, Yang H, Verhaak RGW, Faltas BM, Hansen JB, Wu S, Mischel PS, Henssen AG, Bafna V, Luebeck J, Regenberg B, Luo Y, Lin C, Han P |
| Journal | Cancer Discov |
| Pagination | OF1-OF22 |
| Date Published | 2025 May 07 |
| ISSN | 2159-8290 |
| Abstract | Our comprehensive analysis of ecDNA in urothelial carcinoma reveals its crucial role in driving the evolution and heterogeneity of multifocal cancer, as well as its early involvement in tumorigenesis. Moreover, this study sheds light on immune evasion mechanisms associated with ecDNA and offers valuable insights for developing targeted therapeutic strategies. |
| DOI | 10.1158/2159-8290.CD-24-1532 |
| Alternate Journal | Cancer Discov |
| PubMed ID | 40331621 |
| Grant List | OT2CA278688 / / National Cancer Institute (NCI) / CGCATF-2021/100025 / / Cancer Research UK (CRUK) / 899417 / / European Union's Horizon 2020 research / RR210034 / / Cancer Prevention and Research Institute of Texas (CPRIT) / No. Tsqn202103198 / / Taishan Scholar Foundation of Shandong Province () / |