| Title | Platinum-based chemotherapy inflames the ovarian carcinoma microenvironment through cellular senescence. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Álvarez-Abril B, García-Martínez E, Galluzzi L |
| Journal | Oncoimmunology |
| Volume | 11 |
| Issue | 1 |
| Pagination | 2052411 |
| Date Published | 2022 |
| ISSN | 2162-402X |
| Keywords | Animals, Carcinoma, Ovarian Epithelial, Cellular Senescence, Female, Mice, Ovarian Neoplasms, Platinum, Tumor Microenvironment |
| Abstract | Epithelial ovarian carcinoma (EOC) is virtually insensitive to immune checkpoint inhibitors (ICIs). Recent findings from an innovative mouse model of EOC demonstrate that senescence induction underlies the increased sensitivity of homologous recombination-defective EOCs to platinum-based chemotherapy as it initiates tumor infiltration by immune effector cells coupled to restored sensitivity to ICIs. |
| DOI | 10.1080/2162402X.2022.2052411 |
| Alternate Journal | Oncoimmunology |
| PubMed ID | 35309729 |
| PubMed Central ID | PMC8932912 |