| Title | Using epigenetic modifiers to target cancer stem cell immunoevasion. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Galassi C, Vitale I, Galluzzi L |
| Journal | Cancer Cell |
| Volume | 39 |
| Issue | 12 |
| Pagination | 1573-1575 |
| Date Published | 2021 Dec 13 |
| ISSN | 1878-3686 |
| Keywords | Epigenesis, Genetic, Epigenomics, Humans, Neoplasms, Neoplastic Stem Cells |
| Abstract | Two recent reports in Nature highlight a novel mechanism of immunoevasion that relies on the SET domain bifurcated histone lysine methyltransferase 1 (SETDB1)-dependent epigenetic suppression of endogenous retroelements in melanoma cells. Because SETDB1 is highly expressed by the stem cell compartment, these findings delineate an innovative strategy for restoring cancer stem cell immunosurveillance. |
| DOI | 10.1016/j.ccell.2021.11.003 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 34906316 |