| Title | Transient Autophagy Inhibition Precipitates Oncogenesis: A Red Flag For Pharmacological Autophagy Inhibitors? |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Galluzzi L, Kroemer G |
| Journal | Trends Cell Biol |
| Volume | 30 |
| Issue | 5 |
| Pagination | 339-340 |
| Date Published | 2020 May |
| ISSN | 1879-3088 |
| Keywords | Animals, Autophagy, Carcinogenesis, Humans, Mice, Models, Biological, Treatment Outcome |
| Abstract | Recent findings demonstrate that transient genetic inhibition of autophagy promotes age-associated pathologies in mice. While autophagy restoration effectively counteracts such disorders, it also exacerbates the incidence of various solid and hematological tumors. These data may cast additional shadows on the clinical potential of autophagy inhibition for cancer therapy. |
| DOI | 10.1016/j.tcb.2020.02.004 |
| Alternate Journal | Trends Cell Biol |
| PubMed ID | 32302546 |