Englander Institute for Precision Medicine

Immunogenicity of cell death driven by immune effectors.

TitleImmunogenicity of cell death driven by immune effectors.
Publication TypeJournal Article
Year of Publication2020
AuthorsGalluzzi L, Petroni G, Kroemer G
JournalJ Immunother Cancer
Volume8
Issue1
Date Published2020 Apr
ISSN2051-1426
KeywordsCytotoxicity, Immunologic, Immunogenic Cell Death, Killer Cells, Natural
Abstract

Whether cell death caused by T lymphocytes and natural killer (NK) cells would be immunogenic has been a matter of intense debate. Two back-to-back papers from the Melero's and Pardo's groups have now resolved this conundrum, demonstrating that T and NK cell-mediated cytotoxicity represents indeed a variant of immunogenic cell death.

DOI10.1136/jitc-2020-000802
Alternate JournalJ Immunother Cancer
PubMed ID32253221
PubMed Central IDPMC7174067

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