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Englander Institute for Precision Medicine
Englander Institute for Precision Medicine
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A Modified Mediterranean Ketogenic Diet mitigates modifiable risk factors of Alzheimer's Disease: a serum and CSF-based metabolic analysis.
A Pilot Study on Hyperthermic Intraperitoneal Chemotherapy after Radical or Partial Cystectomy with Pelvic Lymph Node Dissection for High-risk Muscle-invasive Bladder Cancer.
A biologic-device combination product delivering tumor-derived antigens elicits immunogenic cell death-associated immune responses against glioblastoma.
A combinatorial genetic strategy for exploring complex genotype-phenotype associations in cancer.
A deep learning pipeline for automated classification of vocal fold polyps in flexible laryngoscopy.
A guideline on the molecular ecosystem regulating ferroptosis.
A mitochondrial checkpoint to adaptive anticancer immunity.
A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS.
A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas.
A signature of enhanced proliferation associated with response and survival to anti-PD-L1 therapy in early-stage non-small cell lung cancer.
Adaptive inhibition of CGAS signaling by TREX1.
Anti-EGFR Antibodies in the Management of Advanced Colorectal Cancer.
Ariadne: synthetic long read deconvolution using assembly graphs.
Author Correction: Evolution of structural rearrangements in prostate cancer intracranial metastases.
Author Correction: Genetic features and therapeutic relevance of emergent circulating tumor DNA alterations in refractory non-colorectal gastrointestinal cancers.
Author Correction: Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.
Avelumab First-line Maintenance for Advanced Urothelial Carcinoma: Analysis from JAVELIN Bladder 100 by Duration of First-line Chemotherapy and Interval Before Maintenance.
Avelumab first-line maintenance treatment for advanced urothelial carcinoma: review of evidence to guide clinical practice.
BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance.
Bacterial antigens unleash tumor-targeting immunity.
Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer.
Cancer stem cell immunoediting by IFNγ.
Cell death and senescence.
Cellular senescence and aging at the crossroad between immunity and cancer.
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility.
Chromosomal instability drives immunosuppression and metastatic dissemination.
Circulating Tumor DNA Enables Sensitive Detection of Actionable Gene Fusions and Rearrangements Across Cancer Types.
Co-occurring BRCA2/SPOP Mutations Predict Exceptional Poly (ADP-ribose) Polymerase Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer.
Comparative brain metabolomics reveals shared and distinct metabolic alterations in Alzheimer's disease and progressive supranuclear palsy.
Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis.
Correction: Metasurface-enhanced infrared spectroscopy in multiwell format for real-time assaying of live cells.
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production.
Deciphering the origin and therapeutic targets of cancer of unknown primary: a case report that illustrates the power of integrative whole-exome and transcriptome sequencing analysis.
Dual impact of radiation therapy on tumor-targeting immune responses.
Efficacy and Safety of Darolutamide in Combination With Androgen-Deprivation Therapy and Docetaxel in Black Patients From the Randomized ARASENS Trial.
Elevated A-to-I RNA editing in COVID-19 infected individuals.
Endoglin, a Novel Biomarker and Therapeutical Target to Prevent Malignant Peripheral Nerve Sheath Tumor Growth and Metastasis.
Epigenetic memory of coronavirus infection in innate immune cells and their progenitors.
Epinephrine inhibits PI3Kα via the Hippo kinases.
Evolution of structural rearrangements in prostate cancer intracranial metastases.
FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS.
Genetic associations with ratios between protein levels detect new pQTLs and reveal protein-protein interactions.
Genomic sequence context differs between germline and somatic structural variants allowing for their differentiation in tumor samples without paired normals.
Immunogenicity of ferroptosis in cancer: a matter of context?
Immunological aspects of central neurodegeneration.
Immunosurveillance in clinical cancer management.
Immunotherapy in the Treatment of Localized Genitourinary Cancers.
Individual bioenergetic capacity as a potential source of resilience to Alzheimer's disease.
Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma.
Interferon signaling restrains renal cell carcinoma heterogeneity.
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis.
Long-molecule scars of backup DNA repair in BRCA1- and BRCA2-deficient cancers.
Male infertility.
Mapping human natural killer cell development in pediatric tonsil by imaging mass cytometry and high-resolution microscopy.
Metabolomics profiling reveals distinct, sex-specific signatures in the serum and brain metabolomes in the mouse models of Alzheimer's disease.
Mitochondrial control of antigen presentation in cancer cells.
Molecular determinants of immunogenic cell death elicited by radiation therapy.
Molecular features of prostate cancer after neoadjuvant therapy in the phase 3 CALGB 90203 trial.
Multiscale protein networks systematically identify aberrant protein interactions and oncogenic regulators in seven cancer types.
NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.
NIPBL::NACC1 Fusion Hepatic Carcinoma.
Nanoparticle enrichment mass-spectrometry proteomics identifies protein-altering variants for precise pQTL mapping.
Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.
Non-mutational neoantigens in disease.
Noninvasive Detection of Neuroendocrine Prostate Cancer through Targeted Cell-free DNA Methylation.
Outcomes of relapsed clinical stage I versus de novo metastatic testicular cancer patients: an analysis of the IGCCCG Update database.
Pan-cancer proteogenomics characterization of tumor immunity.
Pan-cancer proteogenomics connects oncogenic drivers to functional states.
Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.
Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.
Plain language summary: Can declines in prostate-specific antigen level indicate how long patients with advanced prostate cancer will live when treated with enzalutamide?
Plasma metabolomics profiling of 580 patients from an Early Detection Research Network prostate cancer cohort.
Prognostic value of neutrophil-to-lymphocyte ratio in patients with metastatic castration-resistant prostate cancer receiving prostate-specific membrane antigen targeted radionuclide therapy.
Radiation therapy: An old dog learning new tricks.
Radiopharmaceuticals as combinatorial partners for immune checkpoint inhibitors.
Randomized phase II trial of MRI-guided salvage radiotherapy for prostate cancer in 4 weeks versus 2 weeks (SHORTER).
Recapitulation of patient-specific 3D chromatin conformation using machine learning.
SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor-Induced Growth Suppression.
SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†.
Senolytic treatment reduces oxidative protein stress in an aging male murine model of post-traumatic osteoarthritis.
TIMP1 is an early biomarker for detection and prognosis of lung cancer.
The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer.
The Landscape of US and Global Rare Tumor Research Programs: A Systematic Review.
The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer.
The synthetic phospholipid C8-C1P determines pro-angiogenic and pro-reparative features in human macrophages restraining the proinflammatory M1-like phenotype.
Transcriptomic signatures of chronic active antibody-mediated rejection deciphered by RNA sequencing of human kidney allografts.
Tumor-Associated Lymphocytes and Breast Cancer Survival in Black and White Women.
Type I interferon and cancer.
USING MACHINE LEARNING METHODS TO ASSESS THE RISK OF ALCOHOL MISUSE IN OLDER ADULTS.
Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference.
Voice as an AI Biomarker of Health-Introducing Audiomics.
Whole-Genome Sequencing Analysis of Male Breast Cancer Unveils Novel Structural Events and Potential Therapeutic Targets.
Whole-genome Analysis Elucidates Complex Genomic Events in GLI1 -rearranged Enteric Tumor.
cloudrnaSPAdes: Isoform assembly using bulk barcoded RNA sequencing data.
cloudrnaSPAdes: isoform assembly using bulk barcoded RNA sequencing data.
miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network.
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EIPM Seminar Series | The application of spatial biology for the characterization of Crohn's disease
Precision Medicine Conference | Whole Genome Sequencing of Ovarian Cancer
Town Hall | Englander Institute for Precision Medicine
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Alexandros Sigaras
Alexandros Sigaras
MS
Assistant Professor of Research in Physiology and Biophysics at Weill Cornell Medicine
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