| Title | Autophagy in major human diseases. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Klionsky DJ, Petroni G, Amaravadi RK, Baehrecke EH, Ballabio A, Boya P, San Pedro JManuel Bra, Cadwell K, Cecconi F, Choi AMK, Choi ME, Chu CT, Codogno P, Colombo MIsabel, Cuervo AMaria, Deretic V, Dikic I, Elazar Z, Eskelinen E-L, Fimia GMaria, Gewirtz DA, Green DR, Hansen M, Jäättelä M, Johansen T, Juhász G, Karantza V, Kraft C, Kroemer G, Ktistakis NT, Kumar S, López-Otín C, Macleod KF, Madeo F, Martinez J, Meléndez A, Mizushima N, Münz C, Penninger JM, Perera RM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Santambrogio L, Scorrano L, Simon H-U, Simon AKatharina, Simonsen A, Stolz A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Galluzzi L, Pietrocola F |
| Journal | EMBO J |
| Volume | 40 |
| Issue | 19 |
| Pagination | e108863 |
| Date Published | 2021 Oct 01 |
| ISSN | 1460-2075 |
| Keywords | Animals, Autophagy, Biomarkers, Disease Susceptibility, Gene Expression Regulation, Genetic Predisposition to Disease, Homeostasis, Host-Pathogen Interactions, Humans, Organ Specificity, Signal Transduction |
| Abstract | Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders. |
| DOI | 10.15252/embj.2021108863 |
| Alternate Journal | EMBO J |
| PubMed ID | 34459017 |
| PubMed Central ID | PMC8488577 |
| Grant List | R01 AG021904 / AG / NIA NIH HHS / United States BBS/E/B/000C0413 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom P01 CA114046 / CA / NCI NIH HHS / United States BBS/E/B/000C0417 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom R01 CA260249 / CA / NCI NIH HHS / United States R35 GM131689 / GM / NIGMS NIH HHS / United States R01 AG064892 / AG / NIA NIH HHS / United States UKDRI-2002 / MRC_ / Medical Research Council / United Kingdom R01 CA216242 / CA / NCI NIH HHS / United States R01 AG038664 / AG / NIA NIH HHS / United States R01 CA200310 / CA / NCI NIH HHS / United States P01 AG031782 / AG / NIA NIH HHS / United States R01 CA251726 / CA / NCI NIH HHS / United States R15 GM102846 / GM / NIGMS NIH HHS / United States |