Englander Institute for Precision Medicine

Ca Fluxes and Cancer.

TitleCa Fluxes and Cancer.
Publication TypeJournal Article
Year of Publication2020
AuthorsMarchi S, Giorgi C, Galluzzi L, Pinton P
JournalMol Cell
Volume78
Issue6
Pagination1055-1069
Date Published2020 Jun 18
ISSN1097-4164
KeywordsAnimals, Calcium, Calcium Channels, Calcium Signaling, Humans, Mitochondria, Neoplasms, Signal Transduction, Transient Receptor Potential Channels
Abstract

Ca ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca transporters and other Ca-binding proteins, however, Ca signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca signaling in malignant cells.

DOI10.1016/j.molcel.2020.04.017
Alternate JournalMol Cell
PubMed ID32559424
Grant ListBC180476P1 / / US Department of Defense / International

Weill Cornell Medicine Englander Institute for Precision Medicine 413 E 69th Street
Belfer Research Building
New York, NY 10021