Title | Ca Fluxes and Cancer. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Marchi S, Giorgi C, Galluzzi L, Pinton P |
Journal | Mol Cell |
Volume | 78 |
Issue | 6 |
Pagination | 1055-1069 |
Date Published | 2020 Jun 18 |
ISSN | 1097-4164 |
Keywords | Animals, Calcium, Calcium Channels, Calcium Signaling, Humans, Mitochondria, Neoplasms, Signal Transduction, Transient Receptor Potential Channels |
Abstract | Ca ions are key second messengers in both excitable and non-excitable cells. Owing to the rather pleiotropic nature of Ca transporters and other Ca-binding proteins, however, Ca signaling has attracted limited attention as a potential target of anticancer therapy. Here, we discuss cancer-associated alterations of Ca fluxes at specific organelles as we identify novel candidates for the development of drugs that selectively target Ca signaling in malignant cells. |
DOI | 10.1016/j.molcel.2020.04.017 |
Alternate Journal | Mol Cell |
PubMed ID | 32559424 |
Grant List | BC180476P1 / / US Department of Defense / International |