| Title | Cancer Immunotherapy with CDK7 Inhibitors. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Petroni G, Galluzzi L |
| Journal | Trends Cancer |
| Volume | 6 |
| Issue | 5 |
| Pagination | 361-363 |
| Date Published | 2020 May |
| ISSN | 2405-8025 |
| Keywords | Genomic Instability, Humans, Immunotherapy, Neoplasms |
| Abstract | Recent findings demonstrate that pharmacological cyclin-dependent kinase 7 (CDK7) inhibitors can evoke anticancer immunity upon genomic destabilization of neoplastic cells. Besides adding CDK7 to the expanding list of cell cycle proteins that impinge on immune regulation, these results support the value of aggravating genomic instability in cancer cells to enable immunological disease control. |
| DOI | 10.1016/j.trecan.2020.02.005 |
| Alternate Journal | Trends Cancer |
| PubMed ID | 32348731 |