| Title | Caspase 2 and p53 Reunited in Tumor Control. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Petroni G, Vitale I, Galluzzi L |
| Journal | Trends Cell Biol |
| Volume | 30 |
| Issue | 12 |
| Pagination | 917-918 |
| Date Published | 2020 Dec |
| ISSN | 1879-3088 |
| Keywords | Apoptosis, Caspase 2, Cell Cycle Checkpoints, DNA Breaks, Double-Stranded, DNA Damage, Humans, Neoplasms, Proto-Oncogene Proteins c-mdm2, Radiation, Ionizing, Tumor Suppressor Protein p53 |
| Abstract | Recent findings (Tsabar et al.) demonstrate that human cancer cells that evade the cell cycle blockage normally imposed by DNA damage experience sustained p53 signaling upon MDM2 degradation by caspase 2. Such a response may be connected to the delivery of immunostimulatory signals to ensure the elimination of genetically instable cancer cells. |
| DOI | 10.1016/j.tcb.2020.09.001 |
| Alternate Journal | Trends Cell Biol |
| PubMed ID | 32921524 |