| Title | Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez ABuqué, Chan TA, Coukos G, Demaria S, Deutsch E, Draganov D, Edelson RL, Formenti SC, Fucikova J, Gabriele L, Gaipl US, Gameiro SR, Garg AD, Golden E, Han J, Harrington KJ, Hemminki A, Hodge JW, Hossain DMd Sakib, Illidge T, Karin M, Kaufman HL, Kepp O, Kroemer G, Lasarte JJose, Loi S, Lotze MT, Manic G, Merghoub T, Melcher AA, Mossman KL, Prosper F, Rekdal Ø, Rescigno M, Riganti C, Sistigu A, Smyth MJ, Spisek R, Stagg J, Strauss BE, Tang D, Tatsuno K, van Gool SW, Vandenabeele P, Yamazaki T, Zamarin D, Zitvogel L, Cesano A, Marincola FM |
| Journal | J Immunother Cancer |
| Volume | 8 |
| Issue | 1 |
| Date Published | 2020 Mar |
| ISSN | 2051-1426 |
| Keywords | Consensus, Guidelines as Topic, Humans, Immunogenic Cell Death, Molecular Biology |
| Abstract | Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation. |
| DOI | 10.1136/jitc-2019-000337 |
| Alternate Journal | J Immunother Cancer |
| PubMed ID | 32209603 |
| PubMed Central ID | PMC7064135 |
| Grant List | P01 CA128814 / CA / NCI NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States R01 CA160417 / CA / NCI NIH HHS / United States R01 CA229275 / CA / NCI NIH HHS / United States |