| Title | Immunomodulation by targeted anticancer agents. |
| Publication Type | Journal Article |
| Year of Publication | 2021 |
| Authors | Petroni G, Buqué A, Zitvogel L, Kroemer G, Galluzzi L |
| Journal | Cancer Cell |
| Volume | 39 |
| Issue | 3 |
| Pagination | 310-345 |
| Date Published | 2021 Mar 08 |
| ISSN | 1878-3686 |
| Keywords | Animals, Antineoplastic Agents, Disease Progression, Humans, Immunomodulation, Neoplasms |
| Abstract | At odds with conventional chemotherapeutics, targeted anticancer agents are designed to inhibit precise molecular alterations that support oncogenesis or tumor progression. Despite such an elevated degree of molecular specificity, many clinically employed and experimental targeted anticancer agents also mediate immunostimulatory or immunosuppressive effects that (at least in some settings) influence therapeutic efficacy. Here, we discuss the main immunomodulatory effects of targeted anticancer agents and explore potential avenues to harness them in support of superior clinical efficacy. |
| DOI | 10.1016/j.ccell.2020.11.009 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 33338426 |