| Title | Immunostimulatory effects of radioimmunotherapy. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Constanzo J, Galluzzi L, Pouget J-P |
| Journal | J Immunother Cancer |
| Volume | 10 |
| Issue | 2 |
| Date Published | 2022 Feb |
| ISSN | 2051-1426 |
| Keywords | Adaptive Immunity, Humans, Immune Checkpoint Inhibitors, Immunization, Radioimmunotherapy |
| Abstract | Radiation therapy (RT) is known for its ability to kill cancer cells in an immunogenic manner. Recent preclinical data demonstrate that targeted alpha-particle therapy shares with RT the capacity to elicit immunostimulatory effects, standing out as a promising strategy to circumvent immune checkpoint inhibitor resistance in immunologically 'cold' tumors. |
| DOI | 10.1136/jitc-2021-004403 |
| Alternate Journal | J Immunother Cancer |
| PubMed ID | 35190377 |
| PubMed Central ID | PMC8862476 |