| Title | A mitochondrial checkpoint to NF-κB signaling. |
| Publication Type | Journal Article |
| Year of Publication | 2024 |
| Authors | Guilbaud E, Galluzzi L |
| Journal | Cell Death Dis |
| Volume | 15 |
| Issue | 7 |
| Pagination | 477 |
| Date Published | 2024 Jul 03 |
| ISSN | 2041-4889 |
| Keywords | Animals, Apoptosis, Autophagy, Humans, I-kappa B Kinase, Mitochondria, Mitochondrial Proteins, NF-kappa B, Signal Transduction, Ubiquitination |
| Abstract | Mitochondrial dysfunction can elicit multiple inflammatory pathways, especially when apoptotic caspases are inhibited. Such an inflammatory program is negatively regulated by the autophagic disposal of permeabilized mitochondria. Recent data demonstrate that the ubiquitination of mitochondrial proteins is essential for NEMO-driven NF-kB activation downstream of mitochondrial permeabilization. |
| DOI | 10.1038/s41419-024-06868-3 |
| Alternate Journal | Cell Death Dis |
| PubMed ID | 38961079 |
| PubMed Central ID | PMC11222492 |
| Grant List | R01 CA271915 / CA / NCI NIH HHS / United States U54 CA274291 / CA / NCI NIH HHS / United States |