| Title | Mitochondrial control of innate immune signaling by irradiated cancer cells. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Yamazaki T, Galluzzi L |
| Journal | Oncoimmunology |
| Volume | 9 |
| Issue | 1 |
| Pagination | 1797292 |
| Date Published | 2020 Jul 22 |
| ISSN | 2162-4011 |
| Keywords | DNA, Mitochondrial, Immunity, Innate, Interferon Type I, Mitochondria, Neoplasms, Signal Transduction |
| Abstract | Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells. |
| DOI | 10.1080/2162402X.2020.1797292 |
| Alternate Journal | Oncoimmunology |
| PubMed ID | 32923160 |
| PubMed Central ID | PMC7458622 |