| Title | Multimodal immunostimulation to control BRCA1-defective ovarian carcinoma. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Klapp V, Galluzzi L |
| Journal | Trends Cancer |
| Volume | 8 |
| Issue | 1 |
| Pagination | 1-3 |
| Date Published | 2022 Jan |
| ISSN | 2405-8025 |
| Keywords | BRCA1 Protein, Homologous Recombination, Humans, Immunization, Ovarian Neoplasms |
| Abstract | Depending on intensity and duration, STING1 (stimulator of interferon response cGAMP interactor 1) signaling can restrain or promote tumor progression via both cancer cell-intrinsic and -extrinsic pathways. Bruand et al. recently identified a novel STING1-driven immunosuppressive pathway that can be targeted toward superior disease control in preclinical models of homologous recombination deficient (HRD) ovarian carcinoma. |
| DOI | 10.1016/j.trecan.2021.11.006 |
| Alternate Journal | Trends Cancer |
| PubMed ID | 34840109 |