| Title | Senescence Inflames the Pancreatic Tumor Microenvironment. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Petroni G, Galluzzi L |
| Journal | Cell Rep Med |
| Volume | 1 |
| Issue | 2 |
| Pagination | 100020 |
| Date Published | 2020 May 19 |
| ISSN | 2666-3791 |
| Keywords | Carcinoma, Pancreatic Ductal, CD8-Positive T-Lymphocytes, Humans, Immunotherapy, Pancreatic Neoplasms, Tumor Microenvironment |
| Abstract | Pancreatic adenocarcinomas (PDACs) are scarcely vascularized and thus virtually insensitive to chemotherapy and immunotherapy. In a recent issue of , Lowe and collaborators have demonstrated that senescence induction by MEK plus CDK4/CDK6 inhibitors favors PDAC revascularization coupled to infiltration by therapeutically actionable CD8 T cells. |
| DOI | 10.1016/j.xcrm.2020.100020 |
| Alternate Journal | Cell Rep Med |
| PubMed ID | 33205059 |
| PubMed Central ID | PMC7659541 |