Spatial molecular profiling of a resected pancreatic adenocarcinoma. Fluorescently-labeled probes bind to RNA targets to identify the location of different cell types within a tumor sample. Credit: Jiwoon Park and Rohit Chandwani

Researchers Develop Insights into KRAS Mutations in Pancreatic Cancers

October 4, 2024

A common mutation in the KRAS gene is associated with improved overall survival in pancreatic ductal adenocarcinoma (PDAC) compared with other variants, in part because the mutation appears to lead to less invasiveness and weaker biological activity, according to a multicenter study conducted at Weill Cornell Medicine, ...

Transcription factors are proteins (red, green and dark blue subunits) that control when, where and the degree to which genes are expressed. They bind to specific sequences of DNA (gray and light blue helix) and control the transcription of DNA into mRNA, which is used to build proteins. Credit: Shutterstock

Computational Approach Yields Novel Cancer Targets

September 6, 2024

Researchers at Weill Cornell Medicine have used artificial intelligence to identify drug targets based on mapping regulatory networks in patient tumors. The study, published Sept. 4 in Cell Systems,...

Do Clonal Hematopoiesis and Mosaic Chromosomal Alterations Increase Solid Tumor Risk?

September 6, 2024

Repurposed from Medscape on Friday, September 5, 2024

Do Clonal Hematopoiesis and Mosaic Chromosomal Alterations Increase Solid Tumor Risk?

Clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) are associated with an increased risk for breast cancer, and CHIP is associated...