Englander Institute for Precision Medicine

Publications

Found 28 results
Author Title Type [ Year(Asc)]
Filters: Author is Cantley, Lewis C  [Clear All Filters]
2025
Horne CR, Dite TA, Young SN, Mather LJ, Dagley LF, Johnson JL, Yaron-Barir TM, Huntsman EM, Daly LA, Byrne DP et al..  2025.  PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins.. Proc Natl Acad Sci U S A. 122(8):e2420961122.
2024
Noch EK, Palma L, Yim I, Bullen N, Barnett D, Walsh A, Bhinder B, Benedetti E, Krumsiek J, Gurvitch J et al..  2024.  Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production.. Proc Natl Acad Sci U S A. 121(8):e2317343121.
Klomp JE, J Diehl N, Klomp JA, A Edwards C, Yang R, Morales AJ, Taylor KE, Drizyte-Miller K, Bryant KL, Schaefer A et al..  2024.  Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer.. Science. 384(6700):eadk0850.
Yaron-Barir TM, Joughin BA, Huntsman EM, Kerelsky A, Cizin DM, Cohen BM, Regev A, Song J, Vasan N, Lin T-Y et al..  2024.  The intrinsic substrate specificity of the human tyrosine kinome.. Nature.
Liu J, Cao S, Imbach KJ, Gritsenko MA, Lih T-SM, Kyle JE, Yaron-Barir TM, Binder ZA, Li Y, Strunilin I et al..  2024.  Multi-scale signaling and tumor evolution in high-grade gliomas.. Cancer Cell. 42(7):1217-1238.e19.
Paul S, Sarraf SA, Nam KHong, Zavar L, DeFoor N, Biswas SRanjan, Fritsch LE, Yaron TM, Johnson JL, Huntsman EM et al..  2024.  NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis.. J Cell Biol. 223(2)
Petralia F, Ma W, Yaron TM, Caruso FPia, Tignor N, Wang JM, Charytonowicz D, Johnson JL, Huntsman EM, Marino GB et al..  2024.  Pan-cancer proteogenomics characterization of tumor immunity.. Cell. 187(5):1255-1277.e27.
Wu Y, Foollee A, Chan AY, Hille S, Hauke J, Challis MP, Johnson JL, Yaron TM, Mynard V, Aung OH et al..  2024.  Phosphoproteomics-directed manipulation reveals SEC22B as a hepatocellular signaling node governing metabolic actions of glucagon.. Nat Commun. 15(1):8390.
Sinha NK, McKenney C, Yeow ZY, Li JJ, Nam KHong, Yaron-Barir TM, Johnson JL, Huntsman EM, Cantley LC, Ordureau A et al..  2024.  The ribotoxic stress response drives UV-mediated cell death.. Cell.
Cullati SN, Akizuki K, Chen J-S, Johnson JL, Yaron-Barir TM, Cantley LC, Gould KL.  2024.  Substrate displacement of CK1 C-termini regulates kinase specificity.. Sci Adv. 10(19):eadj5185.
2023
Johnson JL, Yaron TM, Huntsman EM, Kerelsky A, Song J, Regev A, Lin T-Y, Liberatore K, Cizin DM, Cohen BM et al..  2023.  An atlas of substrate specificities for the human serine/threonine kinome.. Nature. 613(7945):759-766.
Darabedian N, Ji W, Fan M, Lin S, Seo H-S, Vinogradova EV, Yaron TM, Mills EL, Xiao H, Senkane K et al..  2023.  Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor.. Nat Chem Biol. 19(7):815-824.
Lin T-Y, Ramsamooj S, Perrier T, Liberatore K, Lantier L, Vasan N, Karukurichi K, Hwang S-K, Kesicki EA, Kastenhuber ER et al..  2023.  Epinephrine inhibits PI3Kα via the Hippo kinases.. Cell Rep. 42(12):113535.
Noch EK, Palma LN, Yim I, Bullen N, Qiu Y, Ravichandran H, Kim J, Rendeiro A, Davis MB, Elemento O et al..  2023.  Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma.. Neuro Oncol. 25(12):2165-2176.
Bhardwaj P, Iyengar NM, Zahid H, Carter KM, Byun DJun, Choi MHo, Sun Q, Savenkov O, Louka C, Liu C et al..  2023.  Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in .. Sci Transl Med. 15(684):eade1857.
Li Y, Porta-Pardo E, Tokheim C, Bailey MH, Yaron TM, Stathias V, Geffen Y, Imbach KJ, Cao S, Anand S et al..  2023.  Pan-cancer proteogenomics connects oncogenic drivers to functional states.. Cell. 186(18):3921-3944.e25.
Jbara A, Lin K-T, Stossel C, Siegfried Z, Shqerat H, Amar-Schwartz A, Elyada E, Mogilevsky M, Raitses-Gurevich M, Johnson JL et al..  2023.  RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.. Nature. 617(7959):147-153.
Higgins CA, Nilsson-Payant BE, Bonaventure B, Kurland AP, Ye C, Yaron TM, Johnson JL, Adhikary P, Golynker I, Panis M et al..  2023.  SARS-CoV-2 hijacks p38β/MAPK11 to promote virus replication.. mBio. :e0100723.
2022
Jang J-Y, Hwang I, Pan H, Yao J, Alinari L, Imada E, Zanettini C, Kluk MJ, Wang Y, Lee Y et al..  2022.  A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.. J Clin Invest. 132(24)
Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin T-Y, Liberatore KM, Bulaon DK et al..  2022.  Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.. Sci Signal. 15(757):eabm0808.
Petroni G, Cantley LC, Santambrogio L, Formenti SC, Galluzzi L.  2022.  Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer.. Nat Rev Clin Oncol. 19(2):114-131.
2021
Han Y, Duan X, Yang L, Nilsson-Payant BE, Wang P, Duan F, Tang X, Yaron TM, Zhang T, Uhl S et al..  2021.  Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.. Nature. 589(7841):270-275.
2020
Liu H, Paddock MN, Wang H, Murphy CJ, Geck RC, Navarro AJ, Wulf GM, Elemento O, Haucke V, Cantley LC et al..  2020.  The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.. Cancer Discov. 10(8):1226-1239.
Rimel JK, Poss ZC, Erickson B, Maas ZL, Ebmeier CC, Johnson JL, Decker T-M, Yaron TM, Bradley MJ, Hamman KB et al..  2020.  Selective inhibition of CDK7 reveals high-confidence targets and new models for TFIIH function in transcription.. Genes Dev. 34(21-22):1452-1473.
2018
Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z et al..  2018.  Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.. Mol Cell. 70(3):531-544.e9.